C50
Conditions
Interventions
Group 1: Survey of the PRS (polygenic risk score) of relatives of non-informatively tested index individuals
Sponsors
Zentrum Familiärer Brust- und Eierstockkrebs Uniklinik Köln
Eligibility
Sex/Gender
Female
Age
30 Years to 45 Years
Inclusion criteria
Inclusion criteria: - Families fulfill the inclusion criteria of the DK-FBREK (see DKG checklist) - Index person is non-informative tested by gene panel analysis. - The person seeking advice has no personal history of breast or ovarian cancer - No other acute, palliative or prognosis-relevant (oncological) disease in personal medical history - First to second degree of kinship (relationship coefficient R = 1/4) to a family member with breast or ovarian cancer - Age between 30 and 50 years (in this age range, inclusion in intensified breast cancer screening is possible in accordance with special care under Section 140a SGB 5) - A possible 2nd genetic line has been excluded or clarified with an index test by gene panel analysis, which resulted in a non-informative genetic finding - Consent to HerediCaRe and to the genetic analysis has been given or will be given as part of the study inclusion
Exclusion criteria
Exclusion criteria: - not fulfilling the above inclusion criteria - lack of capacity to consent - lack of consent - Condition after bilateral mastectomy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Risk change for breast cancer (long time risk and 10 years risk) and any associated “category change” (a change in the risk category and thus the recommendation regarding participation in intensified breast cancer screening). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objective is an exploratory description of the change in risk of ovarian cancer (long time risk in %) | — |
Countries
Germany
Contacts
Public ContactLisa Richters
Zentrum Familiärer Brust- und Eierstockkrebs Uniklinik Köln
Outcome results
None listed