B25.0
Conditions
Interventions
Group 1: Retrospective analysis of intubated and invasively ventilated patients with positive CMV detection in sputum analysis or tracheal secretion. The study will examine adults aged 18 years and ol
Sponsors
Universität Erlangen-Nürnberg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Positive cytomegalovirus (CMV) detection in a sputum analysis or tracheal secretions of intubated and invasively ventilated patients. The presence of ventilation parameters should be documented in the electronic patient record, along with laboratory parameters in the electronic hospital information system (HIS). For this purpose, data from approximately the past ten years should be utilized.
Exclusion criteria
Exclusion criteria: Patients who have already received Ganciclovir prior to CMV detection are excluded from participation in the study. Patients who possess a tracheal cannula as respiratory support but are entirely or partially spontaneously breathing are also excluded. Additionally, patients with a PaO2/FiO2 ratio greater than 300 mmHg are excluded. Immunosuppressed patients are excluded as well. Furthermore, patients undergoing ECMO therapy at the time of Ganciclovir administration are excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary aim of the study is to establish a connection between therapeutic ganciclovir treatment and its effects on ventilation parameters. Secondary study objectives include analyzing infection parameters during ganciclovir therapy, the duration of ventilation under virostatic therapy, and assessing mortality. | — |
Countries
Germany
Contacts
Public ContactAndreas Wehrfritz
Universität Erlangen-Nürnberg
Outcome results
None listed