Performing chest compressions during the initial phase of out-of-hospital cardiac arrest: continuous vs. alternating – a randomised, prospective mannequin study

Performing chest compressions during the initial phase of out-of-hospital cardiac arrest: continuous vs. alternating – a randomised, prospective mannequin study - CALM

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00037157

Enrollment

128

Registered

2025-06-10

Start date

2026-02-11

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Out-of-hospital cardiac arrest

Interventions

Group 1: Continuous chest compressions without personell change Group 2: Alternating chest compressions with personell change

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - informed consent - completed professional training (Participants who completed the first year of the Notfallsanitäterausbildung can participate as Rettungssanitäter/-in)

Exclusion criteria

Exclusion criteria: - inability to perform CPR - study personnel

Design outcomes

Primary

Measure	Time frame
Time until completion of all relevant tasks during the initial CPR phase	—

Secondary

Measure	Time frame
• Chest compression fraction (CCF), chest compression rate, chest compression depth, chest recoil • Number of staff changes • Cumulative no-flow time • Longest pause of chest compressions after starting CPR • Degree of exhaustion and task load, measured by questionnaires • Influence of individual factors on chest compression performance (age, gender, BMI) • Number of interrupted tasks (each interrupted task counts as one) • Time to: beginning of first, second and third rhythm analysis, first and second dose of adrenaline, first dose of amiodarone, first ventilation, secured airway with capnography • Number of deviations from algorithm (shock when not indicated, no shock when indicated, no adrenaline / amiodarone when indicated, adrenaline / amiodarone when not indicated, no rhythm analysis when indicated, staff change when not indicated, no staff change when indicated, endotracheal ventilation without capnography) • Exploratory subgroup analysis between the shockable vs. non-shockable teams for all applicable endpoints.	—

Measure

Time frame

• Chest compression fraction (CCF), chest compression rate, chest compression depth, chest recoil • Number of staff changes • Cumulative no-flow time • Longest pause of chest compressions after starting CPR • Degree of exhaustion and task load, measured by questionnaires • Influence of individual factors on chest compression performance (age, gender, BMI) • Number of interrupted tasks (each interrupted task counts as one) • Time to: beginning of first, second and third rhythm analysis, first and second dose of adrenaline, first dose of amiodarone, first ventilation, secured airway with capnography • Number of deviations from algorithm (shock when not indicated, no shock when indicated, no adrenaline / amiodarone when indicated, adrenaline / amiodarone when not indicated, no rhythm analysis when indicated, staff change when not indicated, no staff change when indicated, endotracheal ventilation without capnography) • Exploratory subgroup analysis between the shockable vs. non-shockable teams for all applicable endpoints.

—

Countries

Germany

Contacts

Public ContactStephan Katzenschlager

Universitätsklinikum Heidelberg

stephan.katzenschalger@med.uni-heidelberg.de+4962215639683

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026