Health promoting potential
Conditions
Interventions
Group 1: B. oleracea smoothie, low biodiversity, for 4 days (once a day), special diet during washout (14 days before intervention) and during intervention
Group 2: B. oleracea smoothie, high biodiver
Sponsors
Universität Augsburg - Medizinische Fakultät, Professur für die Erfoschung umweltebezogener Wirkmechanismen auf die Gesundheit
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: BMI 18.5–30 Non-smoker for at least 10 years Women: confirmed postmenopause (>12 months since last menstruation) Able to understand instructions in German Dietary habits: willingness, if possible, to eat all main meals together during the intervention phases; no eating disorders Compliance: willingness to document all meals during the intervention phases using the GDPR-compliant nutrition app “LogMeal” or as a dietary protocol, and to follow the study requirements Health status: generally good physical and mental health; not in need of care Medication status: no use of antibiotics within the last 3 months before the start of the main study “washout phase”; no use of pre- or probiotics as dietary supplements during the main study; no use of proton pump inhibitors (PPIs), laxatives, metformin, or diuretics during the main study; no polypharmacy (<5 prescription medications/day)
Exclusion criteria
Exclusion criteria: Age: under 55 or over 80 years BMI 30 Smoker or non-smoker for less than 10 years Inability to understand instructions in German Dietary habits: existing strict vegan, ketogenic, or extremely high-fiber diet; eating disorders Health status: severe acute or chronic diseases (e.g., Crohn’s disease, ulcerative colitis, active cancer, severe heart, liver, or kidney disease, autoimmune diseases), need for care, or severe cognitive impairments Medication: use of antibiotics within the last 3 months before the start of the main study; use of pre- or probiotics as dietary supplements during the main study; use of PPIs, laxatives, metformin, or diuretics during the main study; polypharmacy (>5 prescription medications/day) Occupational burden: active shift work Known allergy to Brassicales
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of the gut microbiome (Measured on day 7, 14 and 20) | — |
Secondary
| Measure | Time frame |
|---|---|
| Microbiome-associated normal tissue function, measured in urine and exhaled breath condesate (Urine measurements on day 15, 19 and 20, exhaled breath condensate on day 15 and 19) | — |
Countries
Germany
Outcome results
None listed