Prospective study: analysis of duplex sonographic changes after volume loading of renal patients and analysis of proteomic and histopathologic changes in renal venous congestion

Prospective study: analysis of duplex sonographic changes after volume loading of renal patients and analysis of proteomic and histopathologic changes in renal venous congestion - RENOVAS – RENal VenOus Congestion: Duplex Ultrasound, Proteomic, and Histopathologic Analysis Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00037121

Enrollment

Registered

2025-06-12

Start date

2025-08-01

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

congestive nephropathy N17.8 N18.8 N19

Interventions

Group 1: Analysis of duplex sonographic changes before volume loading of renal patients with indication for renal biopsy Group 2: Analysis of duplex sonographic changes after volume loading of renal p

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: -Kidney disease with indication for kidney biopsy -voluntary participation, ability to give informed consent -Signed informed consent for this study -Legal age

Exclusion criteria

Exclusion criteria: - Refusal of the examination/participation in the study - Lack of possibility to cooperate with the sonography - Underage - Pregnancy or breastfeeding - Patients after kidney transplantation (NTX) - Circumstances that do not allow Doppler sonography to be performed or interpreted (e.g. severe dys-/tachypnea)

Design outcomes

Primary

Measure	Time frame
The primary endpoint is the change in duplex sonographic renal congestion parameters* after volume administration in this patient population. The parameters are measured directly before renal biopsy and directly after volume administration (as standard of care) after renal biopsy. This is done using duplex sonography (ultrasound examination). *Duplex sonographic renal congestion parameters: Here, continuous venous flow (no congestion) can be distinguished from the discontinuous flow patterns pulsatile (mild), biphasic (moderate) and monophasic (severe congestion). The venous impedance index (VII) and the renal venous stasis index (RVSI) are additional duplex sonographic criteria for detecting renal congestion, each of which approaches the value 1 as the degree of congestion increases.	—

Measure

Time frame

The primary endpoint is the change in duplex sonographic renal congestion parameters* after volume administration in this patient population. The parameters are measured directly before renal biopsy and directly after volume administration (as standard of care) after renal biopsy. This is done using duplex sonography (ultrasound examination). *Duplex sonographic renal congestion parameters: Here, continuous venous flow (no congestion) can be distinguished from the discontinuous flow patterns pulsatile (mild), biphasic (moderate) and monophasic (severe congestion). The venous impedance index (VII) and the renal venous stasis index (RVSI) are additional duplex sonographic criteria for detecting renal congestion, each of which approaches the value 1 as the degree of congestion increases.

—

Secondary

Measure	Time frame
1. prevalence of renal congestion in this patient population 2. correlation of renal congestion with underlying disease (e.g. nephrotic vs. non-nephrotic underlying disease) 3. correlation of renal congestion with histopathological parameters (e.g. dilated veins/tubular capillaries) 4. correlation of renal congestion with urinary proteome and metabolome 5. correlation of renal congestion with tissue proteome	—

Measure

Time frame

1. prevalence of renal congestion in this patient population 2. correlation of renal congestion with underlying disease (e.g. nephrotic vs. non-nephrotic underlying disease) 3. correlation of renal congestion with histopathological parameters (e.g. dilated veins/tubular capillaries) 4. correlation of renal congestion with urinary proteome and metabolome 5. correlation of renal congestion with tissue proteome

—

Countries

Germany

Contacts

Public ContactMichael Koziolek

Universitätsmedizin Göttingen

mkoziolek@med.uni-goettingen.de00495513960460

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026