chronic coronary syndrome coronary microvascular disease I20 I25
Conditions
Interventions
Group 1: Patients undergoing clinically indicated coronary angiography due to suspected coronary artery disease are prospectively enrolled in the study.
Before catheterization, the following study-r
Sponsors
Katholisches Klinikum Bochum gGmbH
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: In principle, a signed informed consent form is required for participation in the study. Furthermore: 1. Patients undergoing invasive coronary diagnostics (coronary angiography, coronary microcirculation testing, right heart catheterization) due to typical symptoms (angina pectoris or equivalent symptoms such as exertional dyspnea or chest tightness) and/or signs (e.g., non-invasive evidence of myocardial ischemia) suggestive of coronary artery disease.
Exclusion criteria
Exclusion criteria: 1. History of percutaneous coronary intervention (PTCA, PCI) or coronary artery bypass grafting (CABG). 2. Known advanced renal impairment (eGFR <30 ml/min according to CKD-EPI). 3. Known advanced hepatic dysfunction. 4. Active malignant disease and/or acute or chronic inflammatory or infectious disease. 5. Participation in other medical studies within the past 3 months. 6. Pregnancy. 7. Relevant anemia (Hb <12 g/dl).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Investigation of the coronary microvascular plasma metabolome at rest and during invasive microcirculation testing in patients with and without coronary microvascular dysfunction. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Immunophenotyping of peripheral venous blood and coronary blood at rest and during invasive microcirculation testing in patients with and without coronary microvascular dysfunction. 2. Investigation of the cell-free DNA profile in coronary and whole blood at rest and during invasive microcirculation testing in patients with and without coronary microvascular dysfunction. | — |
Countries
Germany
Contacts
Public ContactArash Haghikia
Katholisches Klinikum Bochum gGmbH
Outcome results
None listed