Perioperative hydrocortisone combined with lavage reduces major complications after pancreaticoduodenectomy in high-risk pancreas

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00037072

Enrollment

226

Registered

2025-06-23

Start date

2025-06-20

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Clinically relevant postoperative pancreatic fistula (CR-POPF), insufficiency of the biliodigestive anastomosis, postoperative hemorrhage (postpancreatectomy hemorrhage, PPH), postoperative pancreatitis, chyle fistula, delayed gastric emptying (DGE), complications requiring reoperation (including completion pancreatectomy), major complications according to Clavien-Dindo grade IIIb–V

Interventions

Group 1: Patients that received perioperative hydrocortisone +- lavage

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: -

Exclusion criteria

Exclusion criteria: -

Design outcomes

Primary

Measure	Time frame
Incidence of major postoperative complications, specifically those classified as Clavien-Dindo grade IIIb–V, following pancreaticoduodenectomy in high-risk patients (ISGPS grade D)	—

Secondary

Measure	Time frame
Incidence of clinically relevant postoperative pancreatic fistula (CR-POPF) Incidence of anastomosis insufficiency, postpancreatectomy hemorrhage, postoperative pancreatitis, chyle fistula, and delayed gastric emptying Reoperation rate (including completion pancreatectomy)	—

Countries

Germany

Contacts

Public ContactBo Kong

Universitätsklinikum Heidelberg

bo.kong@med.uni-heidelberg.de+49 06221 56 310438

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026