Perioperative nociception under general anesthesia during elective outpatient surgery.
Conditions
Interventions
Group 1: In planned outpatient surgeries (e.g., ACL reconstruction), patients’ responses to typical stimuli such as skin incision or drug administration are simultaneously measured and compared during
Sponsors
Universitätsmedizin der Johannes Gutenberg-Universität Mainz Klinik für Anästhesiologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age = 18 years 2. Procedure type Scheduled outpatient procedure (elective ACL reconstruction) 3. Anesthesia method General anesthesia, optionally combined with: – Local anesthesia – Infiltration anesthesia – Regional nerve block 4. Informed consent Ability to give consent; standard preoperative information provided 5. Clinical setting Patient scheduled for surgery at Medical Point Wiesbaden
Exclusion criteria
Exclusion criteria: 1. Cardiac arrhythmias Pre-existing arrhythmias such as atrial fibrillation or AV block (Grade II or III) 2. Cardiac devices Presence of a pacemaker 3. Medication – anticholinergic Preoperative use of parasympatholytic agents 4. Medication – sympathomimetic Preoperative use of sympathomimetic agents 5. Substance abuse Known drug abuse (especially narcotics)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoints include changes in NOL® and qNOX® values in response to predefined nociceptive events. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints comprise hemodynamic parameters (heart rate, mean arterial pressure), EEG-based depth of anesthesia (qCON®), as well as patient age and sex. | — |
Countries
Germany
Contacts
Public ContactAlexander Ziebart
Universitätsmedizin der Johannes Gutenberg-Universität Mainz Klinik für Anästhesiologie
Outcome results
None listed