G30
Conditions
Interventions
Group 1: Systematic assessment of impairment of object recognition and object memory in addition to the routine clinical diagnostics using the VOSP and a computer-based test at baseline and after a fo
Sponsors
Uniklinik Köln
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: • Presentation to a memory clinic due to memory problems reported by the patient or others • Impaired memory performance, assessed using standardized neuropsychological tests • (corrected) adequate vision and hearing, as well as adequate language skills (prerequisite for a differentiated neuropsychological examination)
Exclusion criteria
Exclusion criteria: • Serious pre-existing medical conditions as potential causes of memory impairment (e.g., schizophrenia, psychosis, severe depressive episode, mania, personality disorders, territorial cerebral ischemia, cerebral ischemia with residual deficit, epilepsy, Parkinson's syndrome, history of whole-brain irradiation, cerebrospinal fluid circulation disorders, acute or chronic CNS disease, intracranial malignancies, alcohol or drug addiction) • Inability to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Object recognition assessed using the "Visual object and space perception battery" 2. Object memory and recognition assessed using a computerized test 3. Atrophy of the medial and inferior temporal lobe 4. Longitudinal measures of global cognition and activities of daily living | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Cognitive impairment in other domains 2. CSF-biomarkers of Alzheimer's pathology (Amyloid-ß1-42, phospho-Tau-Protein, total-Tau-Protein) | — |
Countries
Germany
Contacts
Public ContactNils Richter
Uniklinik Köln, Klinik und Poliklinik für Neurologie
Outcome results
None listed