Only healthy test subjects are included.
Conditions
Interventions
Group 1: All treatments are standardized according to currently valid guidelines and follow the order below:
Periodontally healthy, young women (aged 18–35) with regular menstrual cycles are examined.
t=0), cycle day 8-11 (follicular phase
t=1), cycle day 20-23 (luteal phase
t=2) over at least three menstrual cycles
assuming a cycle length of 28 days
If the cycle length differs, the time points t=0, t=1, and t=2 may vary by a few days, individually.
1.) Orienting assessment of the Gingival Bleeding Index (GBI) an
Sponsors
Poliklinik für Zahnerhaltung und Parodontologie, LMU-Klinikum
Eligibility
Sex/Gender
Female
Age
18 Years to 25 Years
Inclusion criteria
Inclusion criteria: - ASA status 1 and 2 - Non-smoker - Consent of the patient - Regular menstrual cycle - Periodontal health (Chapple et al. 2018)
Exclusion criteria
Exclusion criteria: - Children (underage patients) - Poor general condition (ASA status =3) - no consent of the patient to participate in the study - Diagnosed periodontitis disease - Pregnancy, breastfeeding mothers - Taking antibiotics - Diabetes mellitus - Rheumatoid arthritis - Diseases with immunosuppression - Patients with an increased risk of infective endocarditis - Patients with an increased risk of drug-induced jaw necrosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The aim of this prospective study is to analyze associations of the periodontal microbiome and the periodontal expression of immunoregulatory cytokines and reactive metabolites with the menstrual cycle of periodontally healthy young women in order to identify potential cycle-dependent (dental) therapy-relevant biomarkers. 1. changes in the concentration of proinflammatory cytokines and reactive metabolites in saliva and serum at T0, T1, T2 in relation to changes in the concentration of female sex hormones 2. change in the qualitative and quantitative composition of the oral (and possibly vaginal) microbiome at T0, T1, T2 in relation to changes in the concentration of female sex hormones | — |
Countries
Germany
Contacts
Public ContactMatthias Folwaczny
Poliklinik für Zahnerhaltung und Parodontologie, LMU-Klinikum
Outcome results
None listed