K08.9
Conditions
Interventions
Group 1: Patients with periodontitis
500 participants will provide samples such as saliva and blood, which will be analyzed in the lab for several biomarker.
Group 2: Periodontally healthy individuals
Sponsors
LMU Klinikum
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age: = 18 years General health: ASA classification 1 or 2 (healthy or mildly ill) Written informed consent Additionally: Group 1: Diagnosed periodontitis Group 2 (control group): Periodontally healthy individuals
Exclusion criteria
Exclusion criteria: Under 18 years of age Poor general health (ASA classification = 3) Unable to give informed consent Acute inflammatory diseases outside the oral cavity No written consent Fewer than 10 teeth Pregnancy Diseases with immunosuppression or ongoing immunosuppressive therapy Increased risk of infectious endocarditis Increased risk of medication-induced jaw necrosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification of biomarkers that allow prediction of periodontitis progression after therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Characterization of the patient's genome, epigenome, metagenome, and proteome Association of biomarkers (e.g., cytokines, chemokines) with disease severity and progression Analysis of the subgingival microbiota and its role in treatment response | — |
Countries
Germany
Contacts
Public ContactMatthias Fowlaczny
Poliklinik für Zahnerhaltung und Parodontologie
Outcome results
None listed