U09.9
Conditions
Interventions
Group 1: Post-COVID patients
Sponsors
Universitätsklinik und Poliklinik für Radiologie, Universitätsmedizin Halle (Saale)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ? At least one SARS-CoV-2 infection detected by PCR or antigen test more than 3 months ago, ? At least one of the 24 symptoms in the DigiHero study's “Post-COVID Symptoms Follow-up 2” questionnaire or the corresponding questions in the Long COVID Registry (see details in section 10.1) was reported as ‘severe’ (or “mild”) impairment. According to the medical history in the DigiHero study or the Long COVID Registry, the impairing symptoms described as “severe” or “mild” occurred for the first time after a SARS-CoV-2 infection. ? The symptoms cannot be adequately explained by another disease. ? The symptoms have persisted for at least 2 months. ? Symptoms restrict the daily routine of the test subjects, ? Body mass index (BMI) for test subjects between 15 and 35.
Exclusion criteria
Exclusion criteria: ? Subjects who are unable to provide informed consent, ? Pre-existing conditions prior to SARS-CoV-2 infection ? Myalgic encephalomyelitis/chronic fatigue syndrome, ? depression, ? psychosomatic complaints (burnout, borderline personality disorder, obsessive-compulsive disorder, PTSD, eating disorders, phobias, adjustment disorders, anxiety and panic disorders), or ? neurodegenerative diseases such as Alzheimer's disease, ? Pregnancy, ? General contraindications for an MRI examination (claustrophobia, metal parts in the body, implants, hearing aids, pacemakers), ? Gadolinium intolerance, ? Renal insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in the time constants of the recovery of intracellular phosphocreatine (PCr) in muscle tissue after exercise | — |
Secondary
| Measure | Time frame |
|---|---|
| Mitochondrial disorder Disruption of the muscular microcirculation Disruption of microcirculation at the nail fold of the skin Damage to the micro- and macrovasculature in the brain Disturbed regulation of the oxygen concentration in the brain tissue Disruption of the glymphatic transport system in the brain Disturbance of myocardial blood flow, contractility and elasticity Disturbance of cardiac excitation and conduction Presence of myocarditis Disturbance of perfusion/ventilation in the lungs Inflammation Changes in sports medicine Electrophysiological changes in the flexor digitorum superficialis muscle | — |
Countries
Germany
Contacts
Public ContactWalter A. Wolhgemuth
Universitätsklinik und Poliklinik für Radiologie der Universitätsmedizin Halle
Outcome results
None listed