Intensive Care Unit - acquired weakness (ICU-AW)
Conditions
Interventions
Group 1: Patients without pre-existing consumptive disease (subgroup 1, n = 50). Every morning before the resumption of nocturnally paused feeding, blood flow will be measured by ultrasound at the fem
Sponsors
Deutsche Forschungsgemeinschaft
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Intensive care treatment, admitted to intensive care unit within the last 24 hours, immobilization and ventilation for at least 48 hours, written consent
Exclusion criteria
Exclusion criteria: Expected death or termination of life-sustaining measures, femoral venous puncture not feasible, pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterio-venous metabolomics - In the first step, the metabolites are measured there using untargeted liquid chromatography-mass spectrometry in order to distinguish between metabolites that are absorbed or released via the leg. In a second step, the metabolites that differ significantly between arterial and femoral venous blood will be quantified by targeted metabolomics and their absolute uptake or release calculated from arterial blood flow values (Fick's principle). | — |
Secondary
| Measure | Time frame |
|---|---|
| Cross-section of the quadriceps muscles, Urea to creatinine ratio, Intensive Care Unit - length of stay, In-hospital mortality, Hospital - length of stay, SOFA - Score, APACHE II Score, ICU-mobility scale, MRC Score, 6-minute walking test, Short Physical Performance Battery | — |
Countries
Germany
Contacts
Public ContactManfred Blobner
Universitätsklinikum Ulm
Outcome results
None listed