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Cognitive biases in adolescents with anorexia nervosa - an experimental study on mechanisms maintaining psychopathology

Cognitive biases in adolescents with anorexia nervosa - an experimental study on mechanisms maintaining psychopathology - KOALA II

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00036964
Enrollment
135
Registered
2025-05-23
Start date
2025-07-23
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F50.0 F50.1

Interventions

Group 1: CBM-I training: A CBM-I training will be used to modify interpretation biases. CBM-I paradigms attempt to reduce negative interpretation biases by promoting benign (i.e. positive, self-servin
Koster et al., 2009
Matheson et al., 2019). In the present study, the Sentence Word Association Paradigm (SWAP
Dietel et al., 2018) will be used to change body-related interpretation biases. In SWAP training, the participants are first presented with a sentence that describes a self-related ambiguous situatio
in the above example “relaxation”) or negative word (which represents a negative interpretation of the situation described
in the above example “stress”) is then presented and the participants are asked to indicate whether the word is related to the sentence by pressing a button. They should answer as quickly as possible.

Sponsors

Klinik und Poliklinik für Kinder- und Jugenspsychiatrie, Psychosomatik und Psychotherapie, LMU Klinikum
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
12 Years to 19 Years

Inclusion criteria

Inclusion criteria: - Diagnosis of anorexia nervosa or atypical anorexia nervosa according to DSM-5 criteria - At the time of testing, the BMI must correspond to at least the 3rd age-corrected percentile

Exclusion criteria

Exclusion criteria: - below-average intelligence (IQ < 80) - insufficient German language skills - psychotic disorders - bipolar disorders - Substance dependence (except tobacco/nicotine)

Design outcomes

Primary

MeasureTime frame
The primary outcomes of the study are interpretation biases and current eating disorder symptoms. A proximal and a distal measure are used to assess interpretation biases: The assessment version of the SWAP serves as the proximal measure. The task is similar to the training paradigm, but without feedback (cf. Dietel et al., 2020, 2021). An adapted version of the Scrambled Sentences Task (SST) is used as a distal measure. In this task, participants are presented with ambiguous stimuli in form of 6 words and are asked to form grammatically correct sentences from these words under cognitive load and time pressure, whereby either positive or negative sentences can be formed. This additional distal measure is necessary to ensure that changes in interpretation biases can be shown not only with a measure similar to the training paradigm but also generalize to other measures. Current (state) eating disorder symptoms are assessed multimodally: - Subjectively using the Body Image States Scale (BISS) (Cash et al., 2002; Vocks et al., 2007), which records current body (dis)satisfaction by self-report, as well as by an attractivity-rating of one's body following a confrontation with one's body. - Behaviorally and physiologically in the context of a confrontation with one's body in which participants view a previously taken photo of their body (standardized clothing) on a screen (cf. Bauer et al., 2017). During passive viewing, visual attention is recorded via eye tracking and skin conductance and heart rate are recorded as physiological stress indicators (Joormann et al., 2015).

Secondary

MeasureTime frame
In order to examine whether, in addition to current eating disorder symptoms, the CBM-I training also changes more unspecific measures such as self-esteem and affect of the participants, current self-esteem and affect are recorded as secondary outcomes using the state version of the Rosenberg Self-Esteem Scale (RSES-S; see Dietel et al., 2018) and the Positive and Negative Affect Schedule (PANAS; Krohne et al., 1996).

Countries

Germany

Contacts

Public ContactLaura Nuding

Klinik und Poliklinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie, LMU Klinikum

Laura.Nuding@med.uni-muenchen.de+49 89 4400 56962

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 7, 2026