Elastin degradation of the aortic wall as biomarker for thoracoabdominal aortic aneurysm-prediction

Elastin degradation of the aortic wall as biomarker for thoracoabdominal aortic aneurysm-prediction - pDES-TAAA

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00036920

Enrollment

Registered

2025-07-07

Start date

2020-05-01

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I71.6

Interventions

Group 1: TAAA patients (thoracoabdominal aortic aneurysms) This study investigates whether the blood value plasma desmosine (pDES) is suitable as a non-invasive biomarker for thoracoabdominal aortic

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with TAAA, planned for elective, open surgery

Exclusion criteria

Exclusion criteria: Younger than 18 yo, pregnant, did not consent

Design outcomes

Primary

Measure	Time frame
Desmosine levels in plasma – measured using LC-MS/MS; comparison between TAAA patients and controls	—

Secondary

Measure	Time frame
Correlation of plasma desmosine with MMP-2 and TIMP-1 in aortic wall	—

Countries

Germany

Contacts

Public ContactPANAGIOTIS DOUKAS

Universitätsklinikum RWTH Aachen

pdoukas@ukaachen.de+492418036070

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026