F12.1 F12.8
Conditions
Interventions
Group 1: Patients who use cannabinoids or opiods and get an elective operation
Group 2: Cannabinoid and opiate-naive patients undergoing elective surgery
Sponsors
Universitätsklinikum Münster
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients undergoing elective surgery in the fields of a) orthopaedics, b) trauma surgery, c) general surgery, d) urology, e) maxillofacial surgery or f) thoracic surgery operations
Exclusion criteria
Exclusion criteria: 1. Patients who receive epidural or spinal anesthesia 2. Patients with a chronic pain diagnosis 3. Patients who had anesthesia in the last four weeks before the current operation 4. Patients who require ICU treatment 5. Patients requiring mechanical ventilation after leaving the operation room 6. Patients who receive clonidine as medication as part of a disease 7. Patients who receive pregabalin or gabapentin or related active substances as medication in the context of a disease 8. Persons with any kind of dependency on the investigator or employed by the sponsor or investigator. 9. Pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total consumption of anesthetics (opioids, inhaled anesthetics or propofol) for induction and control of intraoperative anesthesia. Measurements in milligrams (mg) of active ingredient either by liquid medication or by vapor measurement for inhaled medications, based on body weight (mg/kg body weight or µg/kg body weight). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Postoperative pain as measured by the Numerical Rating Scale (NRS) 2.Postoperative opioid consumption 3.Intraoperative vasopressor consumption absolute and in µg/kg body weight 4.Time in the post anesthesia care unit until transfer to the normal ward 5.Intraoperative complications defined as a.Tachycardia, defined as a heart rate of more than 100 bpm b.Hypertension, defined as a blood pressure above 140/90 mmHg in 80-year-old patients c.other stress-related reactions d.Impending or actual awakening of the patient from anesthesia, characterized by eye opening, intentional or unintentional limb movements, standing up, sitting up, etc. 6. Nociceptor level index (NOL index) intraoperatively (intubation, during the course) | — |
Countries
Germany
Contacts
Public ContactLudwig Maximilian Schöne
Universitätsklinikum Münster
Outcome results
None listed