Early-onset severe periodontitis (Stage III-IV, Grade C
Conditions
Interventions
Group 1: Patients with very early-onset severe periodontitis (EOPD
stage III/IV, grade C, onset =20 years). A saliva sample is taken for genetic testing (whole exome/genome sequencing) to identify rare disease-associated variants. For follow-up experiments, an additi
Sponsors
Charité - Universitätsmedizin Berlin, Abteilung für Parodontologie, Oralmedizin und Oralchirurgie
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - severe periodontitis (stage III or IV, grade C) - age of onset up to and including 20 years - 1st and 2nd degree relatives regardless of diagnosis
Exclusion criteria
Exclusion criteria: No biological relationship between the family members, e.g. in the case of adoption.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study is a non-interventional, genetic-epidemiological observational study. No therapeutic measures are investigated or compared, therefore no clinical endpoints in the conventional sense are defined. Instead, the study focuses on genetic and molecular biological findings. Primary endpoint (objectives): Identification and molecular characterization of rare genetic variants associated with early-onset severe periodontitis (EOPD) using saliva samples from affected patients and their relatives (Whole Exome or Whole Genome Sequencing). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints (objectives): - Investigation of familial inheritance patterns of the identified variants. - Bioinformatic and molecular biological analysis of potentially disease-relevant molecular effects. - Exploratory identification of predictive diagnostic markers and potential therapeutic targets. | — |
Countries
Austria, Germany, Turkey
Contacts
Public ContactGesa Richter
Charité - Universitätsmedizin Berlin, Abteilung für Parodontologie, Oralmedizin und Oralchirurgie
Outcome results
None listed