This study does not investigate any disease or health condition. It focuses exclusively on the microbial activity of human gut bacteria using anonymized stool samples from healthy adult volunteers.
Conditions
Interventions
Group 1: Healthy adults (=18 years) who voluntarily provide anonymized stool samples for scientific analysis.
The aim is to develop an in vitro model of the human gut microbiota to study the enzymatic
Sponsors
Institut für Mikrobiologie und Biotechnologie, Universität Bonn
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Only healthy participants within the age of 18-65 will be included in the study.
Exclusion criteria
Exclusion criteria: Participants will be excluded if they are taking antibiotics or other medications that could significantly affect the composition of the microbiota.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection and qualitative characterization of enzymatic modifications of xenobiotics by the human gut microbiota using a newly developed in vitro model system. (Based on metabolite profiles identified via HPLC and LC-MS analysis) | — |
Secondary
| Measure | Time frame |
|---|---|
| Establishment and validation of a reproducible, high-throughput-compatible gut microbiota model derived from pooled stool samples, enabling standardized analysis under anaerobic conditions. (Parameters include reproducibility of preparation, microbial composition stability, and technical feasibility) | — |
Countries
Germany
Contacts
Public ContactUwe Deppenmeier
Institut für Mikrobiologie und Biotechnologie, Universität Bonn
Outcome results
None listed