K70.0 K70.1 K70.2 K70.4 K70.9 C22.0 C22.1 C22.2 C22.3 C22.4 C24.0
Conditions
Interventions
Group 1: The indication and listing for liver transplantation are determined at the respective study center following a decision by the transplantation conference and the guidelines for waiting list m
Sponsors
Universitätsklinik für Allgemein-, Viszeral-, Gefäß- und Transplantationschirurgie
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: - Donor Selection • Age = 65 years • Fatty liver disease = 30% (macrovesicular, biopsy if necessary) • No liver fibrosis • No liver cirrhosis • Serum sodium = 160 mg/dL • ICU time = 5 days • Transaminases no more than 5 times the normal values • Cold ischemia time < 10 h • Body weight = 60 kg - Recipient Selection • Age = 18 years • Indication for liver transplantation • Listing for liver transplantation • Consent to the study
Exclusion criteria
Exclusion criteria: Donor • Liver fibrosis • Liver cirrhosis • Age > 65 years • Serum sodium > 160 mg/dL • ICU > 5 days • Transaminases higher than 5 times the normal values • Cold ischemia time = 10 h • Body weight < 60 kg - Recipient • Human liver status • Age < 18 years • Contraindications to liver transplantation according to the Federal Medical Association's Guidelines • No consent to the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Utilization of the existing donor pool through full-right full-left liver split under conditioning using DHOPE | — |
Secondary
| Measure | Time frame |
|---|---|
| • Transplantation of adults with small stature and lower body weight using the full-left split • Compensation for the disadvantage of recipients with low body weight by increasing the number of organs available using the full-left split • Transplantation of patients at an earlier stage of liver disease (lower MELD) by increasing the number of organs available • Early transplantation of HCC patients, thus preventing tumor progression and waiting list dropouts • Non-inferiority in graft and patient survival compared to whole liver transplantation in adult recipients • Evaluation of expanded criteria for a full-right full-left liver split for adult liver transplantation | — |
Countries
Germany
Contacts
Public ContactMareike Franz
Universitätsklinik für Allgemein-, Viszeral-, Gefäß- und Transplantationschirurgie
Outcome results
None listed