physiology /pathophysiology of vascular tone regulation
Conditions
Interventions
Group 1: Small mesenteric arteries obtained from patients who underwent elective colon resection.
Upon receipt of patient tissue samples, small arteries will be dissected and their function investigat
Sponsors
Medizinische Hochschule Brandenburg
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Patients who provide consent that a tissue sample my be obtained for investigations.
Exclusion criteria
Exclusion criteria: manifest peripheral arterial occlusive disease, chronic heart failure NYHA class IV, chronic renal failure stage 3
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is reached when the following question can be answered with sufficient statistical power: Does ex vivo pharmacological inhibition of specific proteinkinases in small arteries from different organs affect vasoconstriction and phosphorylation of proteins critically involved in eliciting vasoconstriction? Depending on the laboratory methods (small vessel myography, stimulation of vessels for protein phsphorylation, transcriptome analyses, morphology), tissue samples will be investigated immediately upon receipt or in preserved form. The lab investigations will be performed in tissue samples that are obtained at a single time point per patient. There is no clinical outcome. | — |
Secondary
| Measure | Time frame |
|---|---|
| There is no secondary outcome, since these are ex vivo investigations in biological samples. | — |
Countries
Germany
Contacts
Public ContactOlaf Grisk
Medizinische Hochschule Brandenburg
Outcome results
None listed