Influence of respiratory rate on the ratio of effective alveolar ventilation to dead space ventilation in controlled ventilated patients. A physiological pilot study.

Influence of respiratory rate on the ratio of effective alveolar ventilation to dead space ventilation in controlled ventilated patients. A physiological pilot study. - RR-Vent

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00036836

Enrollment

Registered

2025-05-07

Start date

2025-05-09

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mechanical Ventilation

Interventions

Group 1: A) Titration of the respiratory rate from 15 - 33/min in 3cmH20 steps, each of which is held for 2 min. Tidal volume is fixed at 6ml/kg IBW, I:E is adjusted to ensure complete expiration. At

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Invasive mechanical ventilation in intensive care patients

Exclusion criteria

Exclusion criteria: Pregnancy Elevated intracranial pressure

Design outcomes

Primary

Measure	Time frame
If the respiratory rate is increased at a fixed tidal volume, the alveolar dead space remains constant as long as complete expiration is ensured.	—

Secondary

Measure	Time frame
- An increase in AMV of 50% above the increase in respiratory rate produces a corresponding decrease in paCO2. - The expiratory time constant provides a reliable estimate of the respiratory rate at which the proportion of effective ventilation decreases. - Expiratory flow limitation is the greatest risk factor for an increase in dead space ventilation.	—

Countries

Germany

Contacts

Public ContactCarolin Jung

Medizinische Hochschule Hannover

jung.carolin@mh-hannover.de+4917615328127

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 29, 2026