Influence of a vancomycin loading dose in the critical early phase of an infection in intensive care patients (adults)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00036829

Enrollment

150

Registered

2025-05-20

Start date

2025-06-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Antibiotic therapy of intensive care patients in the early phase of a severe infection

Interventions

Group 1: Retrospektive Betrachtung von intensivmedizinisch versorgten Patienten, die nach Einführung der hausinternen Handlungsempfehlungen (Anfang 2024) eine körpergewichtsadaptierte Loadingdose zum

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients receiving intensive care with intravenous vancomycin therapy

Exclusion criteria

Exclusion criteria: Patients under 18 years Patients with orally administered vancomycin

Design outcomes

Primary

Measure	Time frame
Proportion of patients with subtherapeutic vancomycin serum levels (= 10mg/l) on day 2 after starting therapy.	—

Secondary

Measure	Time frame
Proportion of patients who develop acute renal failure within 72 hours of starting therapy. By definition, acute renal failure is present if the creatinine level rises by 26.5 µmol/l within 48 hours or increases by 1.5 times the original baseline value	—

Countries

Germany

Contacts

Public ContactAnette Friedrichs

Universitätsklinikum Schleswig-Holstein

anette.friedrichs@uksh.de+49431 11935

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 14, 2026