Evaluation of the Correlation of Gastrointestinal Enhanced Metabolism in the PET-CT with Histopathologic Results

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00036819

Enrollment

140

Registered

2025-09-16

Start date

2021-09-01

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal carcinoma

Interventions

Group 1: Study cohort: Between 2011 and 2020, patients who underwent both an (FDG-)PET-CT and a colonoscopy with biopsy within 12 months were included. PET-CTs were performed using a standardized prot

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: FDG-PET-CT and colonoscopy within 12 month period

Exclusion criteria

Exclusion criteria: FDG-PET-CT without colonoscopy

Design outcomes

Primary

Measure	Time frame
The primary objective of the study is to evaluate the diagnostic potential of (FDG-)PET-CT for detecting colorectal carcinomas and relevant precursor lesions. The endpoint is the correlation of SUVmax values from (FDG-)PET-CT with histological findings from colonoscopy. This parameter is assessed retrospectively by comparing imaging data with pathological biopsy results.	—

Secondary

Measure	Time frame
Secondary endpoints are the determination of the diagnostic accuracy of (FDG-)PET-CT for colorectal lesions by calculating sensitivity, specificity, and positive and negative predictive values. In addition, optimal SUVmax cut-off values are defined using ROC analysis and the Youden index. These parameters are assessed retrospectively through statistical evaluation of imaging and histological data.	—

Measure

Time frame

Secondary endpoints are the determination of the diagnostic accuracy of (FDG-)PET-CT for colorectal lesions by calculating sensitivity, specificity, and positive and negative predictive values. In addition, optimal SUVmax cut-off values are defined using ROC analysis and the Youden index. These parameters are assessed retrospectively through statistical evaluation of imaging and histological data.

—

Countries

Germany

Contacts

Public ContactSebastian Schaaf

Bundeswehrzentralkrankenhaus Koblenz, Klinik für Allgemein-, Viszeral- und Thoraxchirurgie

sebastianschaaf@bundeswehr.org+4926128122001

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026