Non-surgical therapy of intrabony periimplantitis defects by means of subgingival instrumentation and adjunctive antiseptic and hyaluronic acid gel (Clean and Seal)

Non-surgical therapy of intrabony periimplantitis defects by means of subgingival instrumentation and adjunctive antiseptic and hyaluronic acid gel (Clean and Seal) - C&S adjunct in periimplantitis therapy

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

DRKS

Registry ID

DRKS00036786

Enrollment

Registered

2025-05-05

Start date

2024-01-08

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K05.3

Interventions

Group 1: All patients referred to the specialist for treating periimplantitis and diagnosed with intrabony defects around implants will be treated by non-surgical SI together with adjunctive Clean and

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: general healthy condition, T2DM with HbA1c <7,5%, no antiresorptive medication intake

Exclusion criteria

Exclusion criteria: T2DM with HbA1c >=7.5%; pregnancy and lactating period

Design outcomes

Primary

Measure	Time frame
Reduction of Periimplant Probing Depth (PPD) in mm.	—

Secondary

Measure	Time frame
Reduction of BOP in %. Improvment of bone crest position at the implant (MBL = marginal bone level) estimated on the x-ray.	—

Countries

Germany

Contacts

Public ContactAnton Friedmann

UW/H

anton.friedmann@uni-wh.de+492302926655

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026