G90.5 G90.6
Conditions
Interventions
Group 1: Patients with complex regional
CRPS patients (type I and type II, upper and lower extremity) in longitudinal observation with extended diagnostics such as questionnaires, sensory profiles, b
Sponsors
Universitätsklinikum Würzburg
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Persons aged 18-85 years, clinical suspicion or diagnosis of CRPS, recruitment from the Center for Interdisciplinary Pain Medicine, UKW, and by referral.
Exclusion criteria
Exclusion criteria: - Lack of informed consent of the study participant - Pregnancy - Severe renal insufficiency and acute renal failure - Severe hepatic insufficiency - Blood coagulation disorders or medications that result in a severe coagulation disorder - Severe asthma Medications that result in severe coagulation disorders - Severe asthma - With regard to the planned intervention study with anti-IL-6: o Inflammatory rheumatic disease, if under immunosuppressive therapy o Inflammatory neurological diseases, if under immunosuppressive therapy o Current cortisone administration at inclusion o Other autoimmune disease under immunosuppressive therapy (except Hashimoto thyroiditis) o Acute infections o Planned major surgery (within the next 2 weeks) o If necessary study inclusion may be postponed by 2 weeks in the case of acute illnesses
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Parameters that are suitable for 1. checking and objectifying the effect of medication and 2. can be used as additional parameters for a possible composite outcome score. | — |
Primary
| Measure | Time frame |
|---|---|
| Reproducibility of the IL-10/IL-6 ratio within the first 2 weeks as a biomarker predicting pain recovery. | — |
Countries
Germany
Contacts
Public ContactBrenda Gewiß
Universitätsklinikum Würzburg, Klinik und Poliklinik für Anästhesiologie, Intensivmedizin, Notfallmedizin und Schmerztherapie
Outcome results
None listed