Measurement of anesthesia depth in asphyxated neonates during hypothermia treatment
Conditions
Interventions
Group 1: The intervention group consists of 32 neonates born between 2022 to 2024. They were transferred from partner hospitals of Klinikum Oldenburg after suffering asphyxia. They received hypothermi
Sponsors
Klinikum Oldenburg
Eligibility
Sex/Gender
All
Age
No minimum to 1 Days
Inclusion criteria
Inclusion criteria: - Severe acidosis (pH = 7.0 or BG = 16 mmol/L) from cord blood or a blood sample within the first hour of life and - Clinical signs of moderate or severe encephalopathy (grade 2 or 3 according to Sarnat & Sarnat) and - Postnatal age = 6 hours and - Gestational age = 36 weeks If no blood gas analysis is available, a decision can be made based on medical history: - Evidence of fetal hypoxia near birth (e.g., umbilical cord prolapse or rupture, uterine rupture, maternal trauma/hemorrhage, maternal cardiac arrest) and - APGAR score = 5 (after 10 minutes) or ventilation or resuscitation after birth for at least 10 minutes.
Exclusion criteria
Exclusion criteria: - Premature infants under 36+0 weeks of gestation - Contraindications for hypothermia therapy (acute bleeding, poor prognosis with a prenatally known underlying disease, etc.) - Patients in the study group who, contrary to the desired standard, did not receive anesthesia depth monitoring (e.g., due to unavailability of the appropriate equipment)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The cumulative dose of opiates and sedatives administered during neonatal intensive care treatment which will be calculated retrospectively for the entire neonatal intensive care stay manually from archived patient charts. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Time to extubation after reaching Normothermia - Time to discharge from intensive care unit - Time to first enteral feed - Mortality - Prävalence and length of delirium | — |
Countries
Germany
Contacts
Public ContactAxel Heep
Klinikum Oldenburg
Outcome results
None listed