G47.31
Conditions
Interventions
Group 1: Patients with obstructive sleep apnea (OSA-positive group):
- Diagnostic polysomnography with additional EMG electrodes
- Examination of inclusion and exclusion criteria.
- Assignment to the
Sponsors
Universität Marburg
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - OSA (AHI > 5) and healthy control (AHI < 5) - Signed informed consent - Age 18–99 years - Clinically and anamnestically confirmed sleep bruxism - Clinically and anamnestically unconfirmed sleep bruxism
Exclusion criteria
Exclusion criteria: - Neuropathic pain - Respiratory insufficiency - Analgesic medication with potential impact on muscle or respiratory function - Malignant diseases - Severe psychiatric disorders - History of extensive surgeries in the head, jaw, or facial region (e.g., major trauma, cleft lip and palate surgery) - Cognitive impairments - Other sleep disorders (e.g., REM sleep behavior disorder, insomnia, periodic limb movement disorder [PLMD]) - Use of psychotropic medication - < 4 hours of sleep recorded during polysomnography or polygraphy - History of surgical interventions for OSA treatment - Lack of informed consent regarding incidental findings (see MRI consent form) - Cardiac pacemakers - Implantable defibrillators - Left ventricular assist devices (LVADs) - Cochlear implants - Implanted insulin pumps (external pumps must be removed prior to imaging) - Neurostimulators - Penile prostheses - Bladder pacemakers - Ferromagnetic surgical clips, e.g., post-carotid endarterectomy or neurosurgical procedures - Metallic foreign bodies in critical locations (e.g., eye, brain, intrathoracic or vascular regions) - Vascular stents implanted less than 72 hours prior to imaging - Joint prostheses or metallic implants for bone stabilization if implanted less than 6 weeks prior to imaging (Note: Titanium implants are generally MRI-compatible after 6 weeks) - Recent myocardial infarction or vascular stents implanted less than 72 hours ago - Large tattoos with metal-containing pigments - Metallic transdermal or subdermal implants - Piercings must be able to be removed for the examination
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thickness of the masseter muscle | — |
Secondary
| Measure | Time frame |
|---|---|
| - Morphology and position of the hyoid bone - Analyses of thickness, volume, muscle and fat content of other muscles of the masticatory apparatus and pharynx between the OSA-positive and OSA-negative groups as well as sleep bruxists and non-sleep bruxists. - Cortisol level | — |
Countries
Germany
Contacts
Public ContactJanine Sambale
Universität Marburg
Outcome results
None listed