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AI-based evaluation of whole slide images (hematoxylin-eosin staining, OCT3/4 immunohistochemistry, PAS staining) of testicular biopsies in TESE for automated determination of the Bergmann score (according to Bergmann Kliesch 1998)

AI-based evaluation of whole slide images (hematoxylin-eosin staining, OCT3/4 immunohistochemistry, PAS staining) of testicular biopsies in TESE for automated determination of the Bergmann score (according to Bergmann Kliesch 1998)

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00036709
Enrollment
200
Registered
2025-04-28
Start date
2024-11-14
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

N46

Interventions

Group 1: Within the study, testicular biopsy samples obtained during TESE procedures are histologically stained (HE, PAS, OCT3/4) and analyzed using an AI-based system to automatically determine the B

Sponsors

Dr. Senckenbergische Institute für Pathologie und Humangenetik
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Sufficient quality of data coming out of the archive of pathology

Exclusion criteria

Exclusion criteria: Insufficient quality of data

Design outcomes

Primary

MeasureTime frame
Development of an AI-supported system for the automated determination of the Bergmann score in testicular biopsies and comparison of the results between manual and and AI-based evaluation to improve diagnostics and treatment—

Secondary

MeasureTime frame
Comparison of clinical and laboratory parameters with the data obtained from the histopathological examination—

Countries

Germany

Contacts

Public ContactPeter Wild

Dr. Senckenbergische Institute für Pathologie und Humangenetik

simon.gassen@ukffm.de+49 69 6301-5364

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026