Examination of the effect of exogenous ketones in combination with medium-chain triglycerides (MCT) or caffeine on ketosis during physical activity (cycling)

Examination of the effect of exogenous ketones in combination with medium-chain triglycerides (MCT) or caffeine on ketosis during physical activity (cycling) - BiKe

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00036706

Enrollment

Registered

2025-04-29

Start date

2025-05-21

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy subjects, no disease.

Interventions

Group 1: Consumption of an intervention drink with 0.3 g/kg bw exogenous ketones Group 2: Consumption of an intervention drink with 0.3 g/kg bw exogenous ketones and 3 mg/kg bw caffeine Group 3: Consu

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: - BMI 18 - 25 - Active in amateur or professional cycling (existence of a professional contract or activity in a club; training frequency; participation in competitions or similar) - No use of MCT or exogenous ketones in the last 3 months - No known metabolic disease (e.g. lipid metabolism disorder, diabetes mellitus type 1 or 2) - No medication (exception: contraceptives) - No chronic health impairments (e.g. cardiovascular diseases, thyroid gland disorders, intestinal diseases) - no mental or language impairments - no low-carb, ketogenic, vegan or other diet with a permanent reduction in carbohydrate intake (> 50 g carbohydrates/day) - no excessive caffeine consumption (> 400 mg/day; EFSA, 2015) - signature of the declaration of consent - sufficient knowledge of the German language

Exclusion criteria

Exclusion criteria: - Training break of more than 4 weeks during the last 3 months - Taking dietary supplements with an effect on lipid metabolism (e.g. MCT) - Pregnancy/breastfeeding - Simultaneous participation in other studies/study programs - Taking medication (exception: contraceptives) - Allergies/intolerances to the intervention products/ingredients - No consent to participate in the study given - Pregnancy, breastfeeding - Presence of a serious illness or acute illness at the time of the study (including diabetes mellitus) - metabolic diseases that are a contraindication for ketogenic meals - (not yet curated) injuries

Design outcomes

Primary

Measure	Time frame
ß-hydroxybutyrate (capillary blood) Cycling performance (time required to complete the test protocol; watt values generated)	—

Secondary

Measure	Time frame
Cycling performance (time required to complete the test protocol; watt values generated), respiratory acetone, glucose (capillary blood), lactate (capillary blood), subjective fatigue (Borg scale), heart rate, gastrointestinal symptomes	—

Countries

Germany

Contacts

Public ContactTobias Fischer

FH Münster

tobias.fischer@fh-muenster.de+49 251 83-65444

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 7, 2026