Randomized controlled clinical study on bone preservation after tooth extractions with a collagen cone covered with a resorbable magnesium barrier membrane compared to a control group.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00036665

Enrollment

Registered

2025-04-14

Start date

2025-05-07

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone preservation after tooth extraction

Interventions

Group 1: Test group: In 20 patients, a collagen cone made from porcine dermis (collacone, botiss biomaterials GmbH, Zossen, Germany) is inserted into the extraction socket after extraction. The socket

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients who require the extraction of at least one tooth in the upper jaw (15-25). The extraction may be indicated for periodontal reasons or destruction of the tooth due to caries or trauma, which preclude the preservation of the tooth. The missing tooth should be restored with an implant. A requirement for inclusion in the patient group is that a tooth or an existing implant is present in the immediate vicinity of the tooth to be extracted.

Exclusion criteria

Exclusion criteria: • Persons under 18 or legally incompetent persons • Recognizable primary additional need for augmentation • Insertion of the implant with an implant drilling template not possible (insufficient mouth opening). • Heavy smokers (more than 10 cigs/day) • Taking bisphosphonates • Pregnant • Alcohol or drug addicts • Patients with an infectious disease such as hepatitis or HIV/AIDS • Patients with uncontrolled severe diabetes mellitus. The long-term blood sugar level, HbA1c, must be below 6.7%.

Design outcomes

Primary

Measure	Time frame
• Bone loss after tooth extraction. Measured in bucco-oral and mesio-distal direction in millimeters.	—

Secondary

Measure	Time frame
• Changes in the alveolar ridge in relation to the loss of volume of the outer contour measured in cubic millimeters • Bone changes in relation to the loss of volume measured in cubic millimeters • Need for augmentation as a yes/no decision and extent of a planned augmentation • Complications and special events post-surgery, descriptive • Patient satisfaction (VAS)	—

Countries

Germany, Switzerland

Contacts

Public ContactSigmar Schnutenhaus

Zentrum für Zahnmedizin Prof. Dr. Schnutenhaus MVZ GmbH

info@schnutenhaus.de+497731182755

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026