Influence of the timing of a vasopressor administration during anesthesia induction on the incidence of hypotensive events in non-cardiac surgery – an observational study

Influence of the timing of a vasopressor administration during anesthesia induction on the incidence of hypotensive events in non-cardiac surgery – an observational study - PREVENTIVE

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00036641

Enrollment

179

Registered

2025-04-10

Start date

2025-05-21

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I95.2

Interventions

Group 1: Zu der Gabe des Hypnotikums werden über 15 Minuten die Vitalparameter kontinuierlich erhoben, bei Eintreten einer Hypotonie (MAD <65mmHg) wird ein Vasopressor dazu gegeben. Also reaktiv auf e

Eligibility

Sex/Gender

All

Age

45 Years to No maximum

Inclusion criteria

Inclusion criteria: Elective, non-cardiac surgery under general anesthesia Indication for invasive blood pressure monitoring (IBP) according to institutional standard operating procedures (SOPs) Ability to provide informed consent

Exclusion criteria

Exclusion criteria: Pregnant individuals and children Patients unable to understand the study information and/or provide informed consent Preoperative requirement for intensive care Conditions associated with significant inter-arm blood pressure differences Contraindications to the placement of invasive blood pressure monitoring (IBP) Severe aortic stenosis, pheochromocytoma, hypertrophic obstructive cardiomyopathy, heart failure with reduced ejection fraction (HFrEF) Chronic medication with norepinephrine or dopamine reuptake inhibitors, tricyclic antidepressants, or monoamine oxidase inhibitors (MAOIs) End-stage renal disease requiring dialysis (CKD stage 5)

Design outcomes

Primary

Measure	Time frame
PIH – defined as a mean arterial pressure (MAP) < 65 mmHg during the first 15 minutes after induction of anesthesia, quantified as the area under the curve (AUC) below a MAP of 65 mmHg. The unit for this endpoint measurement is mmHg × min (millimetres of mercury multiplied by minutes)	—

Secondary

Measure	Time frame
AUC below MAP thresholds of 60, 50, and 40 mmHg (mmHg × min) Duration of MAP values <65, <60, <50, and <40 mmHg (minutes) Proportion of patients with any MAP measurement <65, <60, <50, and <40 mmHg (%) Proportion of patients with MAP values <65, <60, <50, and <40 mmHg sustained for at least one minute (%) AUC above MAP thresholds of 100, 110, 120, and 140 mmHg (mmHg × min) Standard deviation of MAP (mmHg) Cumulative dose of vasopressors (mg) Cumulative volume of crystalloids administered (ml) Postoperative myocardial injury (defined as an elevation of high-sensitivity troponin T [hsTnT] above the 99th percentile) Postoperative acute kidney injury (AKI), defined as an increase in serum creatinine (sCr) = 0.3 mg/dL within 48 hours Maximum serum creatinine within the first 2 postoperative days Postoperative delirium, assessed in the PACU and on postoperative days 1 and 2 (using Nu-DESC and CAM-ICU) Incidence of ICU admission	—

Measure

Time frame

AUC below MAP thresholds of 60, 50, and 40 mmHg (mmHg × min) Duration of MAP values <65, <60, <50, and <40 mmHg (minutes) Proportion of patients with any MAP measurement <65, <60, <50, and <40 mmHg (%) Proportion of patients with MAP values <65, <60, <50, and <40 mmHg sustained for at least one minute (%) AUC above MAP thresholds of 100, 110, 120, and 140 mmHg (mmHg × min) Standard deviation of MAP (mmHg) Cumulative dose of vasopressors (mg) Cumulative volume of crystalloids administered (ml) Postoperative myocardial injury (defined as an elevation of high-sensitivity troponin T [hsTnT] above the 99th percentile) Postoperative acute kidney injury (AKI), defined as an increase in serum creatinine (sCr) = 0.3 mg/dL within 48 hours Maximum serum creatinine within the first 2 postoperative days Postoperative delirium, assessed in the PACU and on postoperative days 1 and 2 (using Nu-DESC and CAM-ICU) Incidence of ICU admission

—

Countries

Germany

Contacts

Public ContactSascha Treskatsch

Charité - Universitätsmedizin Berlin, Klinik für Anästhesiologie und Intensivmedizin

sascha.treskatsch@charite.de030450551522

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Apr 4, 2026