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Patient-Self Inflicted Lung Injury (P-SILI) in Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrom - Asynchrony between Patient and Ventilator

Patient-Self Inflicted Lung Injury (P-SILI) in Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrom - Asynchrony between Patient and Ventilator - PVentECMOAsynch

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00036618
Enrollment
10
Registered
2025-09-01
Start date
2025-10-01
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

J80

Interventions

Group 1: Sweep Flow Titration The sweep gas flow is reduced from 100% to 75%, 50%, and 25% (potentially down to 0% if medically justifiable) as part of a 5–6 step protocol. It is then increased back t

Sponsors

Universität des Saarlandes
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Informed consent from the patient or a legally authorized representative for participation in the study VV-ECMO therapy Nasogastric tube for Pes measurement

Exclusion criteria

Exclusion criteria: Participants who do not meet the previously specified criteria will be excluded from the study. Persons with impaired legal capacity are excluded from the study unless a legally authorized representative provides consent on their behalf.

Design outcomes

Primary

MeasureTime frame
breath stacking per minute

Secondary

MeasureTime frame
breath stacking per total breaths double triggering per minute reverse triggering per minute Exceedance of a lung-protective tidal volume (>6 ml/kg PBW) as events per study interval (20 minutes) Airway Occlusion Pressure (P0.1) Change in minute ventilation assessed at the end of a study interval

Countries

Germany

Contacts

Public ContactTorben Rixecker

Universität des Saarlandes

torben.rixecker@uks.eu004968411615459

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026