Prospective study of patients with head and neck tumors

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00036603

Enrollment

700

Registered

2025-10-20

Start date

2025-10-20

Completion date

Unknown

Last updated

2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C04

Interventions

Group 1: Patients with head and neck tumors

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Malignoma of the head and neck region

Exclusion criteria

Exclusion criteria: Age under 18 years

Design outcomes

Primary

Measure	Time frame
The primary aim of this study is to investigate the tumor microenvironment in patients with malignancies of the head and neck region. To this end, tumor samples, adjacent tissue samples, as well as blood and saliva specimens are analyzed. The tumor microenvironment plays a central role in regulating the immune response and contributes to the immune evasion of malignant cells. By analyzing expression patterns both at the time of surgery and during the postoperative course, the study aims to examine the extent to which surgical tumor resection is associated with modulation of the systemic immune response. For comparison of immune status, a control group consisting of oncologically healthy patients is included. Blood, saliva, and tissue samples (from healthy oral mucosa) are collected from these individuals at the same time points as from the tumor patients, for example during surgical treatment of fractures. In the long term, the insights gained from this study are expected to enhance the understanding of the immunological tumor microenvironment and provide new starting points for immunotherapeutic interventions in malignancies of the head and neck region.	—

Measure

Time frame

The primary aim of this study is to investigate the tumor microenvironment in patients with malignancies of the head and neck region. To this end, tumor samples, adjacent tissue samples, as well as blood and saliva specimens are analyzed. The tumor microenvironment plays a central role in regulating the immune response and contributes to the immune evasion of malignant cells. By analyzing expression patterns both at the time of surgery and during the postoperative course, the study aims to examine the extent to which surgical tumor resection is associated with modulation of the systemic immune response. For comparison of immune status, a control group consisting of oncologically healthy patients is included. Blood, saliva, and tissue samples (from healthy oral mucosa) are collected from these individuals at the same time points as from the tumor patients, for example during surgical treatment of fractures. In the long term, the insights gained from this study are expected to enhance the understanding of the immunological tumor microenvironment and provide new starting points for immunotherapeutic interventions in malignancies of the head and neck region.

—

Secondary

Measure	Time frame
Additionally, various immune cells are inhibited in vitro using chemotherapeutic agents, immunotherapeutics, and irradiation, in order to evaluate the effects of these treatment modalities on the tumor microenvironment.	—

Countries

Germany

Contacts

Public ContactAnn-Kristin Struckmeier

Universitätsklinikum Hamburg-Eppendorf

a.struckmeier@uke.de+4915114326555

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026