Visualization of peripheral nerves of the upper limb with MSOT

Visualization of peripheral nerves of the upper limb with MSOT - Nerve-MSOT

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00036580

Enrollment

100

Registered

2025-04-07

Start date

2025-04-07

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G62.9

Interventions

Group 1: 100 participants, all undergoing the following activities: - survey questionnaire to gather information on demographics, nerve-related history, and peripheral neuropathy risk factor data such

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: n/a

Exclusion criteria

Exclusion criteria: pregnancy; documented or suspicious light allergy, light intolerance, contact dermatitis, or particularly sensitive skin

Design outcomes

Primary

Measure	Time frame
Determination of specific optoacoustic features of peripheral nerves in the arm compared to the surrounding tissue, recorded with MSOT at rest. These include: a) tissue-specific optoacoustic features (e.g. specific dimensions of endogenous chromophores), b) textural features (e.g. spatial correlations) and c) structural features (fascicle pattern, vascularity, water content, myelin contrast).	—

Secondary

Measure	Time frame
1. Early neuropathic features, such as higher or lower vascularity, altered fascicular patterns and vascularity, myelin contrast, higher/lower water content in participants with higher peripheral neuropathy scores. 2. Peripheral neuropathy risk scores. 3. Quantitative measurement of blood oxygenation of the vasa nervosa – with MSOT and with pulse oximetry readings at the index finger. 4. Quantitative measurement of blood oxygenation in the brachial artery during physiological conditions – via MSOT and with traditional pulse oximetry at the index finger. 5. Segmentation a) based on AI analysis and b) by expert clinician.	—

Measure

Time frame

1. Early neuropathic features, such as higher or lower vascularity, altered fascicular patterns and vascularity, myelin contrast, higher/lower water content in participants with higher peripheral neuropathy scores. 2. Peripheral neuropathy risk scores. 3. Quantitative measurement of blood oxygenation of the vasa nervosa – with MSOT and with pulse oximetry readings at the index finger. 4. Quantitative measurement of blood oxygenation in the brachial artery during physiological conditions – via MSOT and with traditional pulse oximetry at the index finger. 5. Segmentation a) based on AI analysis and b) by expert clinician.

—

Countries

Germany

Contacts

Public ContactDominik Jüstel

Lehrstuhl für Biologische Bildgebung, Technische Universität München

dominik.juestel@tum.de+49 89 41407211

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026