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Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00036561

Enrollment

Registered

2025-04-01

Start date

2025-04-02

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E66.0

Interventions

Group 1: The present study aims to evaluate the influence of positive end-expiratory pressure (PEEP) on end-expiratory lung impedance, pulmonary ventilation distribution, lung mechanics and volume, ga

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Performance of a bariatric procedure at Mannheim University Hospital - Presence of grade 3 obesity (body mass index = 50kg/m2) - Consent to participate in the study

Exclusion criteria

Exclusion criteria: - Age < 18 years - Chronic lung diseases

Design outcomes

Primary

Measure	Time frame
Delta end-expiratory lung impedance (delta EELI) between baseline general anesthesia (PEEP 8 cmH2O) and PEEP level with highest static compliance of the respiratory system	—

Secondary

Measure	Time frame
- Delta EELI between different PEEP levels - Delta alveolar collapse between the start and end of the decremental PEEP trial (delta collapse PEEP 24-6 cmH2O) - Parameters of the pulmonary ventilation distribution - Ventilation parameters and pressures - Esophageal pressures and transpulmonary pressures - Lung mechanics - Gas exchange - Hemodynamics	—

Countries

Germany

Contacts

Public ContactJörg Krebs

Universitätsmedizin Mannheim

Joerg.Krebs@umm.de+49 0621 383 3233

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026

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