Retrospective Investigation of Circadian Disruption and Clinical Phenotypes in ICU Patients with COVID-19 (CP-COVID-19)

Retrospective Investigation of Circadian Disruption and Clinical Phenotypes in ICU Patients with COVID-19 (CP-COVID-19) - CP-COVID-19

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00036535

Enrollment

2500

Registered

2025-04-08

Start date

2025-04-16

Completion date

Unknown

Last updated

2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F05.0

Interventions

Group 1: This retrospective project includes the analyses of 3 working packages of COVID-19 patients who were treated in the intensive care units of Charité - Universitätsmedizin Berlin between 01.01.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - All patients with COVID-19 disease, proven by positive PCR tests from nasal / throat swab and samples from the deep respiratory tract. - Period 01.01.2020 to 21.02.2022

Exclusion criteria

Exclusion criteria: • None

Design outcomes

Primary

Measure	Time frame
Working packages 1 and 2: Delirium (yes/no), diagnosed using standardized scales such as the Confusion Assessment Method for the ICU (CAM-ICU) or as a sign of oversedation using the Richmond Agitation-Sedation Scale (RASS). Measurement: from ITS admission to ITS discharge Working package 3 Accuracy of the prediction models measured with “area under the receiver operating characteristic curve (AUROCC)”	—

Measure

Time frame

Working packages 1 and 2: Delirium (yes/no), diagnosed using standardized scales such as the Confusion Assessment Method for the ICU (CAM-ICU) or as a sign of oversedation using the Richmond Agitation-Sedation Scale (RASS). Measurement: from ITS admission to ITS discharge Working package 3 Accuracy of the prediction models measured with “area under the receiver operating characteristic curve (AUROCC)”

—

Secondary

Measure	Time frame
Duration of delirium: The duration of delirium in patients, measured in days. Measurement: from ITS admission to ITS discharge Ventilation hours (non-invasive, invasive) Measurement: from ITS admission to ITS discharge Type of ventilation Measurement: from ITS admission to ITS discharge Routine laboratory parameters Measurement: from ITS admission to ITS discharge Medication administered, Measurement: from ITS admission to ITS discharge Duration of treatment in hospital and ICU. Adverse events, defined by: thromboembolic events, noscomial infections, septic shock, acute renal failure, myocardial infarction, PICS and death Measurement: from ITS admission to hospital discharge. PICS: Measurement: 90, 180 days after hospital discharge Data from the PICS outpatient clinic (medication plan, routine PICS examinations, etc.) Measurement: 90, 180 days after hospital discharge ITS - Mortality Hospital - mortality Organ failure (SOFA score) Measurement: from ITS admission to ITS discharge Data on intensive care treatment (e.g. organ replacement therapies, nutritional therapy, interventions, results of routine examinations) Measurement: from ITS admission to ICU discharge Timestamp from the Health Data Platform Measurement: from ITS admission to ICU discharge	—

Measure

Time frame

Duration of delirium: The duration of delirium in patients, measured in days. Measurement: from ITS admission to ITS discharge Ventilation hours (non-invasive, invasive) Measurement: from ITS admission to ITS discharge Type of ventilation Measurement: from ITS admission to ITS discharge Routine laboratory parameters Measurement: from ITS admission to ITS discharge Medication administered, Measurement: from ITS admission to ITS discharge Duration of treatment in hospital and ICU. Adverse events, defined by: thromboembolic events, noscomial infections, septic shock, acute renal failure, myocardial infarction, PICS and death Measurement: from ITS admission to hospital discharge. PICS: Measurement: 90, 180 days after hospital discharge Data from the PICS outpatient clinic (medication plan, routine PICS examinations, etc.) Measurement: 90, 180 days after hospital discharge ITS - Mortality Hospital - mortality Organ failure (SOFA score) Measurement: from ITS admission to ITS discharge Data on intensive care treatment (e.g. organ replacement therapies, nutritional therapy, interventions, results of routine examinations) Measurement: from ITS admission to ICU discharge Timestamp from the Health Data Platform Measurement: from ITS admission to ICU discharge

—

Countries

Germany

Contacts

Public ContactClaudia Spies

Klinik für Anästhesiologie und Intensivmedizin (CCM/CVK) Charité- Universitätsmedizin Berlin, Campus Virchow - Klinikum

claudia.spies@charite.de+49 30 450 55 12 98

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026