C71
Conditions
Interventions
Group 1: At the start of the study, a baseline MRI (3T) is performed, including structural 3D T1-weighted imaging and resting-state fMRI, to identify suitable target regions for TMS. Within 1–30 days,
Sponsors
Klinik und Poloklinik für Radiologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with suspected glioma or confirmed glioma (biopsied but not resected), as well as patients with suspected cerebral metastases or confirmed metastases (biopsied but not resected). Capacity to give informed consent. Eligibility for MRI without contraindications.
Exclusion criteria
Exclusion criteria: An urgent need for neurosurgical intervention due to a mass lesion or brain swelling. Known pregnancy. Claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in the tumor-associated disconnectivity index (DCI) during transcranial magnetic stimulation (TMS) compared to baseline resting-state fMRI. Measurements are taken before TMS, during the first MRI scan, and simultaneously during the TMS-fMRI session (1–30 days after the baseline MRI). Data collection is performed using functional MRI (fMRI). An analysis of BOLD signal correlations between the tumor and tumor-associated brain regions to calculate the DCI is also conducted. | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression-free survival and overall survival according to RANO criteria for gliomas (Wen et al. 2023) and brain metastases (Lin et al. 2015). Additionally, motor function (BMRC), speech (modified AAT), and cognitive function (MOCA test). | — |
Countries
Germany
Contacts
Public ContactSophia Stöcklein
Klinik und Poloklinik für Radiologie
Outcome results
None listed