Impact of Applying a Reduced Oxygen Concentration Before Extubation on the Functional Residual Capacity in Patients with Obesity - a randomized controlled clinical trial

Impact of Applying a Reduced Oxygen Concentration Before Extubation on the Functional Residual Capacity in Patients with Obesity - a randomized controlled clinical trial - OXY-REDUCE

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00036465

Enrollment

Registered

2025-03-24

Start date

2025-08-01

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obese patients undergoing surgery with general anesthesia

Interventions

Group 1: Obese patients with a BMI > 30 kg/m2 undergoing elective laparoscopic surgery with general anesthesia and endotracheal intubation who will be extubated with an FiO2 ( inspiratory oxygen conce

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Patients undergoing an elective laparoscopic surgical procedure under general anesthesia with endotracheal intubation - BMI = 30 kg/m² and = 40 kg/m² - Expected intubation duration = 1 hour - Informed consent obtained

Exclusion criteria

Exclusion criteria: - Previous lung surgery - Known or expected difficult intubation (despite the use of a video laryngoscope) - Persistent hemodynamic instability - Severe COPD or bronchial asthma (non-invasive ventilation and/or long-term oxygen therapy, repeated systemic corticosteroid administration due to frequent exacerbations) - Immunosuppressive medication or radiation therapy within the last months before inclusion - Heart failure = NYHA III, acute cardiac syndromes - Pregnancy (exclusion by history or lab test) - Severe pulmonary arterial hypertension, defined as a systolic pulmonary arterial pressure > 40 mmHg - Increased intracranial pressure - Any neuromuscular disease - Implanted heart support systems, pacemakers, or ICDs - Intraoperative abdominal or lateral positioning - Procedures with one-lung ventilation - Cardiac/thoracic surgical procedures - Neurosurgical procedures - Enrollment in another interventional study according to the German Medicines Act (AMG)/Medical Devices Act (MDPG) or failure to consent to participation in the study

Design outcomes

Primary

Measure	Time frame
Difference in Functional Residual Capacity (FRC) 30 min after extubation compared to baseline before induction of general anesthesia = ?FRC 30 min after extubation (FIO2 0.5) vs. ?FRC 30 min After Extubation (FIO2 1.0)	—

Secondary

Measure	Time frame
- Ventro-dorsal ventilation distribution measured by electrical impedance tomography (EIT) - Arterial partial pressure of oxygen (paO2)	—

Countries

Germany

Contacts

Public ContactPhilipp Simon

Universitätsklinikum Augsburg

philipp.simon3@uk-augsburg.de+49 821 400 2378

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026