Cognitive performance and quality of life after neurosurgical operations for benign brain tumors in advanced age

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00036458

Enrollment

Registered

2025-10-06

Start date

2025-11-25

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

D32.0 D35.2 D33 D33.3

Interventions

Group 1: The study investigates the cognitive performance and quality of life in patients aged 65 and older following the surgical removal of benign brain tumours (e.g., meningiomas, pituitary adenoma

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: • Age = 65 years • Diagnosed benign brain tumor (e.g., meningiomas, pituitary adenomas) • Ability to provide consent and complete the tests

Exclusion criteria

Exclusion criteria: • Malignant brain tumors or metastases • Severe psychiatric disorders or preoperative dementia (MMSE <20) • Surgical contraindications

Design outcomes

Primary

Measure	Time frame
The primary outcome of the study is the postoperative deterioration of cognitive performance in the assessed questionnaires/scores after surgical removal of benign brain tumours. Standardised instruments such as the Montreal Cognitive Assessment (MoCA), the SF-36 RAND Version 1.0, WHOQOL-BREF, G8 screening and - if screening is positive - a practical geriatric assessment including Mini-Cog and Gait Speed Test are used for this purpose. To detect postoperative delirium, the Nursing Delirium Screening Scale (NuDESC) is employed. Assessments are conducted preoperatively as well as 1 week, 3 months and 15 months postoperatively. The results are correlated with surgical variables (e.g., duration of surgery, blood loss), neurological deficits, and tumour characteristics. The study aims to identify predictive factors for cognitive and functional recovery to improve decision-making and patient counselling.	—

Measure

Time frame

The primary outcome of the study is the postoperative deterioration of cognitive performance in the assessed questionnaires/scores after surgical removal of benign brain tumours. Standardised instruments such as the Montreal Cognitive Assessment (MoCA), the SF-36 RAND Version 1.0, WHOQOL-BREF, G8 screening and - if screening is positive - a practical geriatric assessment including Mini-Cog and Gait Speed Test are used for this purpose. To detect postoperative delirium, the Nursing Delirium Screening Scale (NuDESC) is employed. Assessments are conducted preoperatively as well as 1 week, 3 months and 15 months postoperatively. The results are correlated with surgical variables (e.g., duration of surgery, blood loss), neurological deficits, and tumour characteristics. The study aims to identify predictive factors for cognitive and functional recovery to improve decision-making and patient counselling.

—

Secondary

Measure	Time frame
Postoperative deterioration in quality of life as reported in the questionnaires/scores.	—

Countries

Germany

Contacts

Public ContactMarián Banas

Neurochirurgie, Klinikum Fürth

neurochirurgie@klinikum-fuerth.de+4991175802010

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 14, 2026