F43.1
Conditions
Interventions
Group 1: Patients with post-traumatic stress disorder are placed in an experimentally induced social evaluation situation (social evaluation task), during and after which the following is examined:
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Sponsors
Klinik für Psychosomatische Medizin und Psychotherapie, Universitätsklinikum Münster (UKM)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: - Diagnosis F43.1 according to ICD-10 - Healthy control subjects - Age from 18 - 65 years - Voluntary consent to the measures to be carried out in the study
Exclusion criteria
Exclusion criteria: General: - People under 18 and older than 65 years - Pregnancy - Serious chronic physical illnesses (e.g. autoimmune diseases, diabetes, heart disease or cancer) - Taking certain medications: o Regular use of psychotropic drugs that affect the central nervous system (e.g. opripramol, quetiapine, SSRIs, zopiclone, benzodiazepines) o corticosteroids o Immunosuppressants o Hormone therapies o Medications that affect the heart rate (e.g. ß-blockers) o Regular use of cannabis Exclusion criteria for patients: - Social phobia - Psychotic, bipolar or dementia disorders, severe depression, substance dependence, borderline personality disorder Exclusion criteria for control group: - Current presence of PTSD or other mental disorders, measured with PCL-5, ITQ and SCID-5 - Severe traumatic experiences according to ICD-10, measured with LEC
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcomes are: - Concentration of pro- and anti-inflammatory markers (pro: IL-6, TNF-a, anti: IL-10) - Feelings of fear, shame, anger as a result of the social evaluation task (SET) and over time - Heart rate and HRV during and after SET - Verbal memory performance in free recall of the SET adjectives | — |
Secondary
| Measure | Time frame |
|---|---|
| - Psychological diagnoses according to DSM-V, recorded by the clinical interview SCID-5 - Self-assessed severity of PTSD symptoms, recorded using the PTSD Symptom Checklist (PCL-5) according to DSM-V and the International Trauma Questionnaire (ITQ) according to ICD-11 - Fear of negative Evaluation (FNE-K) - Emotion regulation (Emotion Regulation Questionnaire, ERQ; S-DERS; Emotion Beliefs Questionnaire, EBQ) - Depressive symptoms (PHQ-9), anxiety symptoms (GAD-7) and other state and trait questionnaires | — |
Countries
Germany
Contacts
Public ContactMarkus Ramm
Klinik für Psychosomatische Medizin und Psychotherapie, Universitätsklinikum Münster (UKM)
Outcome results
None listed