Influence on mean arterial pressure during initiation of extracorporeal circulation under different perfusion regimes

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00036397

Enrollment

Registered

2025-03-14

Start date

2025-06-16

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with cardiac care with bypasses under the protection of the heart-lung machine

Interventions

Group 1: The aim of this randomized intervention study is to investigate a collective of 60 patients of 60 patients, who are divided into 2 groups of n = 30 patients each by means of block randomizati

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Only patients with electively planned isolated coronary surgery will be included in the study.

Exclusion criteria

Exclusion criteria: Hemodynamically unstable patients or those treated as emergencies will not be included in the study. Patients with a preoperative hemoglobin concentration < 9g/dl are also excluded.

Design outcomes

Primary

Measure	Time frame
Application of ECC initiation for safe perfusion and maintenance of the MAD under controlled relief of the cardiovascular system. In the study group, care is taken to ensure that every 30 seconds a flow increase of a quarter (25%) of the calculated HZV is achieved every 30 seconds. After the measurements are documented and all data have been collected, the patient's routine therapy is continued with the agreement of the surgeon and the anesthesiologist. HZV Group A (study group)Time Group A (study group) 25% 30 sec. 50% 60 sec. 75% 90 sec. 100% 120 sec. In the control group, care is taken to ensure that a flow increase of a quarter (25%) of the calculated HZV is achieved every 7.5 seconds. HZV Group B (control group) Time Group B (control group) 25% 7,5s 50% 15,0s 75% 22,5s 100% 30,0s The measurements begin with the start of the heart-lung machine and are performed at the times specified above. After reaching full flow, the measurements of the standard parameters are documented for a further 5 minutes. All other standard parameters will continue to be recorded during the operation.	—

Measure

Time frame

Application of ECC initiation for safe perfusion and maintenance of the MAD under controlled relief of the cardiovascular system. In the study group, care is taken to ensure that every 30 seconds a flow increase of a quarter (25%) of the calculated HZV is achieved every 30 seconds. After the measurements are documented and all data have been collected, the patient's routine therapy is continued with the agreement of the surgeon and the anesthesiologist. HZV Group A (study group)Time Group A (study group) 25% 30 sec. 50% 60 sec. 75% 90 sec. 100% 120 sec. In the control group, care is taken to ensure that a flow increase of a quarter (25%) of the calculated HZV is achieved every 7.5 seconds. HZV Group B (control group) Time Group B (control group) 25% 7,5s 50% 15,0s 75% 22,5s 100% 30,0s The measurements begin with the start of the heart-lung machine and are performed at the times specified above. After reaching full flow, the measurements of the standard parameters are documented for a further 5 minutes. All other standard parameters will continue to be recorded during the operation.

—

Secondary

Measure	Time frame
Checking the correlation of norepinephrine administration in the two groups.	—

Countries

Germany

Contacts

Public ContactLauren Lees

Helios Klinik für Herzchirurgie Karlsruhe

lauren.lees@gmx.de+49 721 – 9738 147

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 10, 2026