Role of the NO-sGC-cGMP axis in vasopressor dependent sepsis

Role of the NO-sGC-cGMP axis in vasopressor dependent sepsis - NOSEP

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00036370

Enrollment

295

Registered

2025-06-05

Start date

2025-08-15

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A41

Interventions

Group 1: Patients who had been included in the SISPCT-trial are eligible for this study. A random sample is drawn from the original SISPCT study population for further analysis. From each of these pat

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients having participated in SISPCT-trial (independent of group assignment) IFNgamma-phenotyping available

Exclusion criteria

Exclusion criteria: Missing informed consent for biobanking

Design outcomes

Primary

Measure	Time frame
Time-course of cGMP plasma-concentration in patients with sepsis	—

Secondary

Measure	Time frame
Time course of the components of the NO-sGC-cGMP-axis as well as the RAAS-system in plasma Time course of the proteom and markers of inflammation in plasma Correlation of the components of the NO-sGC-cGMP-axis as well as the RAAS-system and the proteom with vasopressor need, 28 day and 90 day mortality, IFNgamma-phenotype, and organ dysfunctions	—

Countries

Germany

Contacts

Public ContactMichael Bauer

Universitätsklinikum Jena - Klinik für Anästhesiologie und Intensivmedizin

michael.bauer@med.uni-jena.de+49 3641-9323101

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026