ALtitude Performance Study: Characterization of Performance and Its Influencing Factors During Acute Altitude Exposure

ALtitude Performance Study: Characterization of Performance and Its Influencing Factors During Acute Altitude Exposure - ALPS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00036351

Enrollment

Registered

2025-03-27

Start date

2025-01-10

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

T70.2

Interventions

Group 1: For the study, healthy subjects with minor, non-study-relevant medical conditions will be recruited. Non-invasive measurement methods will be used to assess performance capacity at low altitu

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Healthy participants with non-study-related, minor conditions (e.g., stable, treated hypothyroidism, orthopedic complaints).

Exclusion criteria

Exclusion criteria: Fear of riding cable cars, clinically manifest heart disease (e.g., coronary artery disease), relevant pulmonary diseases, or other serious conditions with the risk of acute deterioration.

Design outcomes

Secondary

Measure	Time frame
Pulmonary diagnostics include lung function testing (ventilatory parameters, diffusion capacity), blood gas analysis (pO2, pCO2, acid-base balance), blood sampling (e.g., NT-proBNP, endothelin, differential blood count), exhalate analysis (FeNO, CO2), oscillography, and shunt measurement. Cardiac diagnostics involve echocardiography and vascular ultrasound (e.g., LVEF, sPAP, TR Vmax, pulmonary fluid), blood sampling (e.g., NT-proBNP), ECG (electrical conduction changes, especially under exertion), and heart rate variability measurement (e.g., via smartwatch). Hemodynamic diagnostics include continuous noninvasive arterial pressure monitoring (stroke volume, cardiac output, pulse wave analysis), blood pressure measurements, and heart rate determination. Fluid balance analysis comprises bioimpedance analysis to assess body composition and its changes, urine analysis (e.g., urine osmolality, proteinuria, urinary electrolytes), and blood sampling for electrolyte changes. Metabolic analysis includes blood sampling (e.g., bicarbonate, pH, lactate), dietary intake logging, and exhalate analysis. Sleep analysis consists of polygraphy or polysomnography (e.g., AHI, desaturation index).	—

Measure

Time frame

Pulmonary diagnostics include lung function testing (ventilatory parameters, diffusion capacity), blood gas analysis (pO2, pCO2, acid-base balance), blood sampling (e.g., NT-proBNP, endothelin, differential blood count), exhalate analysis (FeNO, CO2), oscillography, and shunt measurement. Cardiac diagnostics involve echocardiography and vascular ultrasound (e.g., LVEF, sPAP, TR Vmax, pulmonary fluid), blood sampling (e.g., NT-proBNP), ECG (electrical conduction changes, especially under exertion), and heart rate variability measurement (e.g., via smartwatch). Hemodynamic diagnostics include continuous noninvasive arterial pressure monitoring (stroke volume, cardiac output, pulse wave analysis), blood pressure measurements, and heart rate determination. Fluid balance analysis comprises bioimpedance analysis to assess body composition and its changes, urine analysis (e.g., urine osmolality, proteinuria, urinary electrolytes), and blood sampling for electrolyte changes. Metabolic analysis includes blood sampling (e.g., bicarbonate, pH, lactate), dietary intake logging, and exhalate analysis. Sleep analysis consists of polygraphy or polysomnography (e.g., AHI, desaturation index).

—

Primary

Measure	Time frame
The aim of the study is to characterize the performance of healthy subjects under conditions of hypobaric hypoxia during real or simulated altitude exposure using non-invasive measurement methods (VO2max, max. watt, delta watt/HR).	—

Countries

Germany

Contacts

Public ContactJeremias Götschke

Medizinische Klinik und Poliklinik V, LMU Klinikum

pneumologie@med.uni-muenchen.de089 4400 52590

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026