The influence of water conservation mechanisms on sarcopenia, inflammation and immunosuppression in hemodialysis patients

The influence of water conservation mechanisms on sarcopenia, inflammation and immunosuppression in hemodialysis patients - SkInDialysis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00036332

Enrollment

Registered

2025-03-10

Start date

2025-01-06

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

N18

Interventions

Group 1: Investigation of the Skin Barrier • Measurements over 4 weeks: before dialysis, every 30 minutes during dialysis, and after dialysis. • Measurement parameters: o TEWL (transepidermal water lo

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Hemodialysis

Exclusion criteria

Exclusion criteria: No consent

Design outcomes

Primary

Measure	Time frame
Primary outcome measure: Change in transepidermal water loss (g/h/m²) before, during, and after hemodialysis Rationale: Robust, species-independent parameter, numerically easy to assess, low methodological susceptibility to interference Measurement method: Tewameter® TM Hex (Courage + Khazaka Electronic, Cologne) Analysis: Depending on normal distribution Use of non-parametric or parametric tests for paired samples (matched pairs)	—

Measure

Time frame

Primary outcome measure: Change in transepidermal water loss (g/h/m²) before, during, and after hemodialysis Rationale: Robust, species-independent parameter, numerically easy to assess, low methodological susceptibility to interference Measurement method: Tewameter® TM Hex (Courage + Khazaka Electronic, Cologne) Analysis: Depending on normal distribution Use of non-parametric or parametric tests for paired samples (matched pairs)

—

Secondary

Measure	Time frame
1) Change in Copeptin levels due to hemodialysis as a marker of neurohumoral activation (ELISA measurement in serum before and after hemodialysis). 2) Investigation of serum concentrations of nitrogen metabolism-related metabolites (Anserine, Copeptin, Glutamine/Glutamate, Aspartate) and their changes due to hemodialysis (serum measurement before and after hemodialysis, serum metabolomics analysis using ultra-high-performance liquid chromatography (UHPLC) with MxP® Quant 500 Kit, biocrates). 3) Analysis of TonEBP mRNA expression using RT-PCR in isolated neutrophils, monocytes, and myeloid-derived suppressor cells (MDSCs) (blood sampling before & after dialysis in weeks 1 and 4).	—

Measure

Time frame

1) Change in Copeptin levels due to hemodialysis as a marker of neurohumoral activation (ELISA measurement in serum before and after hemodialysis). 2) Investigation of serum concentrations of nitrogen metabolism-related metabolites (Anserine, Copeptin, Glutamine/Glutamate, Aspartate) and their changes due to hemodialysis (serum measurement before and after hemodialysis, serum metabolomics analysis using ultra-high-performance liquid chromatography (UHPLC) with MxP® Quant 500 Kit, biocrates). 3) Analysis of TonEBP mRNA expression using RT-PCR in isolated neutrophils, monocytes, and myeloid-derived suppressor cells (MDSCs) (blood sampling before & after dialysis in weeks 1 and 4).

—

Countries

Germany

Contacts

Public ContactJohannes Wild

Philipps-Universität Marburg

wildjo@med.uni-marburg.de+4964215866481

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026