H18.5
Conditions
Interventions
Group 1: 50 patients with typical changes in EBMD (Epithelial Basement Membrane Dystrophy)
Group 2: 50 healthy test subjects (control group)
Sponsors
Uniaugenklinik Frankfurt am Main
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Adults over the age of 18 who have characteristic clinical morphological findings of EBMD (e.g. maps, dots, fingerprint, corneal erosions) and associated classic clinical symptoms such as blurred vision, glare, recurrent foreign body sensation or epiphora. For the comparison group, healthy subjects without corneal changes and symptoms are included. All subjects must be able to understand the requirements of the study and give written informed consent before the start of the study.
Exclusion criteria
Exclusion criteria: Eyes with a history of surgery or trauma to the cornea or other cornea-related pathologies cornea or other cornea-related pathologies (such as keratoconus, pterygium, corneal scars, corneal dystrophies or degenerations other than EBMD) are not included in the study. The same applies to eyes in which vision is impaired due to diseases of the lens, retina or optic nerve optic nerve (e.g. age-related macular degeneration, diabetic retinopathy, optic atrophy or advanced clouding of the lens) are severely and irreversibly impaired, are not primarily considered in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The refraction determined objectively using the autorefractometer shows no significant difference to the subjectively measured refraction measured subjectively. (primary null hypothesis) | — |
Secondary
| Measure | Time frame |
|---|---|
| The best-corrected visual acuity determined using the objectively measured refraction shows no significant difference to the visual acuity determined using the best-corrected visual acuity measured by subjective refraction (secondary null hypothesis) | — |
Countries
Germany
Contacts
Public ContactIngo Schmack
Uniaugenklinik Frankfurt am Main
Outcome results
None listed