Influence of dietary supplementation with maritime pine bark extract (Pycnogenol®) on the sensitivity of the glycocalyx of erythrocytes to sodium

Influence of dietary supplementation with maritime pine bark extract (Pycnogenol®) on the sensitivity of the glycocalyx of erythrocytes to sodium - PycnoGlyx

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00036277

Enrollment

Registered

2025-05-26

Start date

2025-06-02

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Salt sensitivity of erythrocytes

Interventions

Group 1: Seven-day intake of 300 mg Pycnogenol®

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Healthy men/women aged 18 to 65 years Signed informed consent

Exclusion criteria

Exclusion criteria: Any known systemic diseases or regular drug treatment Course of antibiotic treatment within the past 4 weeks Intake of dietary supplements Pregnant and breastfeeding women

Design outcomes

Primary

Measure	Time frame
Influence of maritime pine bark extract (Pycnogenol®) on the salt sensitivity of the erythrocyte glycocalyx as determined by sedimentation rates (pre-post measurement)	—

Secondary

Measure	Time frame
Presence of the of the microbial metabolite of Pycnogenol (5-(3’,4’-dihydroxy¬phenyl)-?-valerolactone; called “M1”) in saliva and correlation with the degree of salt sensitivity of the erythrocyte glycocalyx. Concentrations of other parameters in saliva, such as lipoprotein a, in order to evaluate potential factors correlating with salt sensitivity. Exploratory in vitro studies of glycoclayx-associated endothelial parameters	—

Measure

Time frame

Presence of the of the microbial metabolite of Pycnogenol (5-(3’,4’-dihydroxy¬phenyl)-?-valerolactone; called “M1”) in saliva and correlation with the degree of salt sensitivity of the erythrocyte glycocalyx. Concentrations of other parameters in saliva, such as lipoprotein a, in order to evaluate potential factors correlating with salt sensitivity. Exploratory in vitro studies of glycoclayx-associated endothelial parameters

—

Countries

Germany

Contacts

Public ContactPetra Högger

Pharmazeutische Chemie und Lebensmittelchemie, Universität Würzburg

petra.hoegger@uni-wuerzburg.de0931 31-85468

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 29, 2026