F84.0 F84.1 F84.5
Conditions
Interventions
Group 1: The study is divided into three or more study days, each separated by approximately two years. Children and Adolescents aged 11 to 18 years with and without autism spectrum disorder are inclu
Sponsors
Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters
Eligibility
Sex/Gender
All
Age
11 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1) Age: 11-18 years at the time of the first wave 2) The presence of a clinical diagnosis of autism spectrum disorder according to ICD-10 3) Achievement of research criteria for ASD: ADI-R cut-off met in two of the four subscales 4) For control subjects: no psychiatric diagnosis and inconspicuous values in the CBCL, FBB-ADHS, FBB-SSV and SRS questionnaires
Exclusion criteria
Exclusion criteria: 1) Intelligence quotient < 70 2) Contraindications to the collection of MRI data 3) Current or past drug and/or alcohol abuse 4) Use of antipsychotics, antidepressants and/or benzodiazepines
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Clinical questionnaire data (AQ, CBCL, FBB-ADHS, FBB-SSV,FSK, RBS-R, SRS, Handedness) for wave 1, wave 2 and possibly some additional timepoints. 2) MRI data: sMRI (cortical thickness, surface area, cortical volume, local gyrification, geodesic distance), DTI (Fractional Anisotropy, Mean Diffusivity), rsfMRI (BOLD signal) for wave 1, wave 2 and possibly some additional timepoints. | — |
Secondary
| Measure | Time frame |
|---|---|
| Intelligence test (Wechsler Abbreviated Scale of Intelligence, WASI); autism specific diagnostic tools (ADOS, ADI-R) for wave 1, wave 2 and possibly some additional timepoints. | — |
Countries
Germany
Contacts
Public ContactChristine Ecker
Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters
Outcome results
None listed