G35.0
Conditions
Interventions
Group 1: The intervention-free pre-baseline phase includes two testing sessions for motor hand and arm function, motor imagery ability, and movement imitation within 7–9 days. After 1–3 days, an intro
Sponsors
Reha Zentrum Münster
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Men, women, and people of diverse genders with a diagnosis of MS according to the currently valid version of the (revised) McDonald criteria (McDonald et al., 2001; Polman et al., 2011; Thompson et al., 2018) • Functional impairment of one or both upper extremities, such as muscle weakness, active movement restriction of the shoulder, elbow, wrist, and/or fingers, sensory disturbance, spastic movement disorder, and tremor, determined by a neurological specialist examination • Age between 18 and 99 years • Expanded Disability Status Scale (EDSS) (Kurtzke, 1983) score between 4.0 and 8.5 • All MS phenotypes (relapsing-remitting MS [RRMS], primary progressive MS [PPMS], secondary progressive MS [SPMS] (Lublin & Reingold, 1996)) • Intact cognitive function based on a neurological examination and combined oral or written Symbol Digit Modalities Test (SDMT) (Smith, 1973) with z-scores > -1.5 (Filser et al., 2018) and Mini Mental Status Test [MMST] scores = 24/30 (Tombaugh & McIntyre, 1992) • Any ethnicity • German speaking, both orally and in writing
Exclusion criteria
Exclusion criteria: • Comorbidity that, according to the judgement of the study physicians, could prevent or impair participation in the study (e.g., malignant diseases, other neurological, psychiatric, or severe orthopaedic-rheumatologic conditions) • Recent surgical interventions on the joints or soft tissues of the upper extremities or cervical spine and significant osteoarthritis, inflammatory conditions, and pain in the upper extremity • Untreated significant impairment of vision or hearing • An MS relapse within the 3 months prior to the study and during the study period • In the case of a medication change that could affect the results, patients may be excluded from the study at the discretion of the study physicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.1Motor imagery ability - Mental chronometry (ratio of imagined versus performed Box and Blocks Test, BBT). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoints will be: 2.1 Gross motor function of the hand - Box and Blocks Test (BBT) 2.2 Fine motor function of the hand - Nine Hole Peg Test (NHPT) 2.3 Motor function of the arm – Action Research Arm Test (ARAT) 2.4 Mental rotation of the hand, shoulder, and neck - validated Laterality Application from the Noigroup (Neuro Orthopaedic Institute, Adelaide, Australia) 2.5 Ability to imagine movements kinaesthetically and visually - Kinaesthetic and Visual Imagery Questionnaire-10 (KVIQ-10) 2.6 Ability to imitate hand and finger gestures - Test for the Imitation of Finger and Hand Gestures according to Goldenberg (1996) 2.7 Experiences with AOMI – semi-structured interview 2.8 Suggestions for optimising AOMI of the upper extremities - semi-structured interview 2.9 Practicability of conducting AOMI of the upper extremities - semi-structured observation. Adherence to the intervention will also be evaluated here. For all quantitative assessments, the validated German version will be used, which have shown good to excellent psychometric properties. | — |
Countries
Austria
Contacts
Public ContactJanice Habig
Reha Zentrum Münster
Outcome results
None listed