B97.4
Conditions
Interventions
Group 1: Description of the local mucosal and the systemic immune response in the nose as the primary site of infection:
a. Which cell populations dominate? Are there any differences to RSV-uninfected
Sponsors
Universitätsklinikum Düsseldorf
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: - Study participants are patients of the University Hospital Düsseldorf - Consent to participate in the study by the parents or legal guardians and consent to participation by the study participant (from pre-school age) - Symptoms indicative for a respiratory infection and/or PCR or POCT test positive for RSV (target group) or alternatively RSV PCR or POCT test negative for RSV (control group, preferably comparable in terms of age and previous illnesses)
Exclusion criteria
Exclusion criteria: - No consent to the study - Age =18 years - Study participation is not reasonable at this time for health reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification of immunological characteristics for severe RSV courses: - Differences in the immune cell population in the mucosa between RSV-infected and uninfected children - Changes in the early mucosal and the systemic immune response (e.g. altered gene expression of immune factors) Molecular biological characterization of RSV strains in severe vs. mild courses - Genotypic and phenotypic description of circulating virus strains - Possible identification of new virus clusters First indications of the occurrence of escape variants under the influence of nirsevimab | — |
Secondary
| Measure | Time frame |
|---|---|
| - Correlation between clinical parameters and immune/viral characteristics - Correlation between disease severity and individual parameters (e.g. age, previous illnesses, socio-economic aspects) | — |
Countries
Germany
Contacts
Public ContactJörg Timm
Universitätsklinikum Düsseldorf
Outcome results
None listed