Immunisation as potential resilience mechanism

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00036183

Enrollment

170

Registered

2025-03-13

Start date

2018-09-05

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F32

Interventions

Group 1: UNCON-HSE: Enhanced perceived self-efficacy by once providing fake positive feedback on stress coping based on filled-in questionnaires. Subsequently uncontrollable stress task: 45 trials of

Eligibility

Sex/Gender

All

Age

18 Years to 30 Years

Inclusion criteria

Inclusion criteria: Normal weight (BMI between 18.5 and 26), sufficient German language skills, male or female gender identity

Exclusion criteria

Exclusion criteria: Current psychological axis I disorder according to the DSM-IV, current or lifetime psychotherapy or psychiatric hospitalization, psychiatric medication, tinnitus, hearing problems, skin problems at the sites of electrode attachment, dyslexia, left-handedness.

Design outcomes

Primary

Measure	Time frame
Perceived control: Assessed with the item "How much control do you have over the stimuli" on a 7-point Likert scale at 5 time points during the stress task after every 9th trial.	—

Secondary

Measure	Time frame
Self-efficacy: Assessed with the item "If you think about the future, how do you rate your ability to cope with stressful and difficult situations?" on a 5-point Likert scale before and after the self-efficacy manipulation. Perceived helplessness: Assessed with the item "How helpless do you feel with regard to the stimuli" on a 7-point Likert scale at 5 time points during the stress task after every 9th trial. Aversiveness: Assessed with the item "How unpleasant are the stimuli for you?" on a 7-point Likert scale at 5 time points during the stress task after every 9th trial. State depression and anxiety: Assessed with the German state version of the State-Trait Anxiety and Depression Inventory (STADI-S) before and after the stress task. Negative affect: Assessed with the German Positive and Negative Affect Schedule (PANAS) before and after the stress task.	—

Measure

Time frame

Self-efficacy: Assessed with the item "If you think about the future, how do you rate your ability to cope with stressful and difficult situations?" on a 5-point Likert scale before and after the self-efficacy manipulation. Perceived helplessness: Assessed with the item "How helpless do you feel with regard to the stimuli" on a 7-point Likert scale at 5 time points during the stress task after every 9th trial. Aversiveness: Assessed with the item "How unpleasant are the stimuli for you?" on a 7-point Likert scale at 5 time points during the stress task after every 9th trial. State depression and anxiety: Assessed with the German state version of the State-Trait Anxiety and Depression Inventory (STADI-S) before and after the stress task. Negative affect: Assessed with the German Positive and Negative Affect Schedule (PANAS) before and after the stress task.

—

Countries

Germany

Contacts

Public ContactMichèle Wessa

Zentralinstitut für Seelische Gesundheit (ZI)

michele.wessa@zi-mannheim.de+49 621 1703-7490

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026